دوره 1، شماره 4 - ( 9-1396 )
جلد 1 شماره 4 صفحات 8-1 |
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Arab Zoozani M, Ghaemi E A, Jamalli A. Frequency of AmpC β-lactamase Resistance in Escherichia coli Isolates from Urinary Tract Infections in Gorgan, Iran. jcbr 2017; 1 (4) :1-8
URL: http://jcbr.goums.ac.ir/article-1-96-fa.html
URL: http://jcbr.goums.ac.ir/article-1-96-fa.html
عرب زوزنی مهدی، قائمی عزت اله، جمالی آیلر. Frequency of AmpC β-lactamase Resistance in Escherichia coli Isolates from Urinary Tract Infections in Gorgan, Iran. Journal of Clinical and Basic Research. 1396; 1 (4) :1-8
چکیده: (4605 مشاهده)
Introduction: AmpC β-lactamases are among the most important cephalosporinases. Production of AmpC β-lactamase in microorganisms is often associated with multidrug resistance and limited treatment options. This study aimed to determine antimicrobial susceptibility pattern and frequency of AmpC β-lactamase genes in Escherichia coli strains isolated from urinary tract infections. Materials and Methods: The study included 154 E. coli isolates from urine samples of patients in medical centers of Gorgan, Iran. Cefoxitin-resistance was evaluated by the Kirby-Bauer method. Cefoxitin-resistant strains were evaluated using cefoxitin disks alone and combined with boronic acid to confirm presence of AmpC β-lactamase. Presence of MOX gene was investigated by polymerase chain reaction. Results: Among the 154 E. coli isolates, 37 (24%) were cefoxitin-resistant, 16 of which were found to be AmpC β-lactamase-positive in the phenotypic test. In addition, the MOX gene was found in two isolates. Conclusions: The frequency of AmpC β-lactamase-producing E. coli and MOX gene in Gorgan is close to the regional and national average.
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