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Nasr ali S, Mohammed Omar A M R, Alhama H. Clinical and Histopathological Evaluations of Testicular Regression Syn-drome: A Case Report. jcbr 2020; 4 (2) :15-19
URL: http://jcbr.goums.ac.ir/article-1-251-en.html
1- Department of Paediatrics, Faculty of Medicine, Minia University, Minia, Egypt؛ Hamad Medical Corporation, Doha, Qatar , sabrynasraly@yahoo.com
2- Department of Pathology, Faculty of Medicine, Minia University, Minia, Egypt;Al Emadi Hospital, Doha, Qatar
3- Department of Paediatric Surgery, Pediatric University Hospital, Damascus, Syria; Al Emadi Hospital, Doha, Qatar
Abstract:   (2287 Views)
Background: Testicular regression syndrome (TRS) is defined as the partial or total absence of testicular tissue in 46XY patients with normal external genitalia. The incidence of TRS has been reported to be less than 5% in patients with cryptorchidism. Herein, we report a case of a one-year old boy who underwent surgical exploration with an initial diagnosis of cryptorchidism.
Case description: a one-year old male came to the outpatient clinic at Al Emadi Hospital, Doha, Qatar. Physical examination revealed normal external genitalia with palpable right testis and non-palpable left testis. The initial diagnosis was cryptorchidism. Testicular structure was not identified and a presumed testicular remnant in the left superficial inguinal ring was sent for histological examination. The histological examination revealed a fibrovascular nodule, spermatic cord structures, calcification and hemosiderin deposits supporting the diagnosis of TRS.
Conclusion: When patient fulfills clinical and pathological criteria for TRS, we should consider the possibility of orchiopexy and testicular prosthesis implantation to decrease the risk of testicular torsion and negative psychological effects.
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Article Type: Research | Subject: Basic medical sciences
Received: 2020/07/14 | Accepted: 2020/05/21 | Published: 2020/05/21

1. Smith NM, Byard RW, Bourne AJ. Testicular regression syndrome a pathological study of 77 cases, individuals with normal external genitalia. Histopathology 1991; 19:269-72. [View at Publisher] [DOI] [Google Scholar]
2. Diamond DA, and Caldamone AA. The value of laparoscopy for a 106 impalpable testis relative to clinical presentation. J Urol 1992; 148:632-634. [View at Publisher] [DOI] [PubMed] [Google Scholar]
3. Pirgon O, and Dundar BN. Vanishing testes: a literature review. J Clin Res Pediatric Endocrinol 2012; 4:116-120. [View at Publisher] [DOI] [PubMed] [Google Scholar]
4. Spires SE, Woolums CS, Pulito AR, Spires SM. Testicular regression syndrome. a clinical and pathologic study of 11 cases. Arch Pathol Lab Med 2000; 124:694-8. [View at Publisher] [PubMed] [Google Scholar]
5. Nistal M, and Paniagua R. Non-neoplastic diseases of the testis. Urologic surgical pathology. 2nd ed. Mosby Elsevier; 2008. p632 5. [View at Publisher] [DOI] [Google Scholar]
6. Bader MI, Peeraully R, Ba'Ath M, McPartland J, Baillie C. The testicular regression syndrome, do remnants required routine excision? J Pediatr Surg 2011; 46:384-6. [View at Publisher] [DOI] [PubMed] [Google Scholar]
7. Kogan S, Hadziselimovic F, Howards SS, Synder HM III, Huff DS. Pediatric andrology. In: Adult and Pediatric Urology1996:2623-2674. [View at Publisher] [Google Scholar]
8. Merry C, Sweeney B, Puri P. The vanishing testis: anatomical and histological findings. Eur Urol1997; 31:65-67. [View at Publisher] [DOI] [PubMed] [Google Scholar]
9. Nishizawa S, Suzuki K, Tachikawa N,Nukui A, Kumamaru T, Shioji Y, et al. The vanishing testis: diagnosis and histological findings. Nihon Hinyokika Gakkai Zasshi 2000; 91:537-541. [View at Publisher] [DOI] [PubMed] [Google Scholar]
10. Ambulkar PS, Waghmare JE,Tarnekar AM, Shende MR, Ghosh SK,Pal AK. positive 46, XY male with vanishing testis syndrome, feminization and gynecomastia. [View at Publisher] [PubMed] [Google Scholar]
11. Desai A, Verma R, ParabM. A Case of Testicular Regression Syndrome. The Internet Journal of Surgery 2008 [View at Publisher]
12. Desai A, Verma R, ParabM. A Case of Testicular Regression Syndrome. The Internet Journal of Surgery 2008 [View at Publisher]
13. Ali M S., Mathew M., Testicular Regression Syndrome: Useful Diagnostic Approach IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-ISSN: 2279-0853, p-ISSN: 2279-0861.Volume 17, Issue 1 Ver. 13 January. (2018), PP 07. [View at Publisher] [Google Scholar]
14. Rozanski T.A, Wojno K.J, Bloom D.A. The remnant orchiectomy. J Urol 1996; 155: 712-714. [View at Publisher] [DOI:10.1016/S0022-5347(01)66507-8] [PubMed] [Google Scholar]
15. Bodiwala D, Summerton DJ, Terry TR. Testicular prosthesis: development and modern usage. Ann R Coll Surg Engl. 2007;89(4):349-53. [View at Publisher] [DOI:10.1308/003588407X183463] [PubMed] [Google Scholar]

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