[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 2, Issue 4 (Journal of Clinical and Basic Research(JCBR) 2018) ::
jcbr 2018, 2(4): 0-0 Back to browse issues page
Overexpression of Long Non-Coding RNA POU3F3 in Esophageal Squamous Cell Carcinoma is Associated with TNM Stage and Family History
Halime Rahimnia 1, Abdolvahab Moradi 2, Naemeh Javid 2, Yasaman Fateri 1, Shabbou Bahramian 2, Zahra Roohinejad 2, Hossein Sabouri 3, Eisa Jorjani * 1
1- Department of Biology, Gonbad Kavous University, Gonbad Kavous, Iran
2- Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran
3- *Correspondence: Eisa Jorjani, Department of Biology, Gonbad Kavous Univers
Abstract:   (44 Views)
Background and objectives: Esophageal cancer (EC) is the second most common gastrointestinal cancer, and esophageal squamous cell carcinoma (ESCC) is the dominant type of EC in Iran. One of the most important challenges in cancer management is the early diagnosis. As tumor suppressors or oncogenes, long non-coding RNAs (lncRNAs) play a vital role in tumor initiation, progression and metastasis. Recent studies have reported dysregulated expression of lncRNAs in different tumor tissues including ESCC, which may indicate its prognostic or diagnostic potential in ESCC. In this study, we investigated expression pattern of lnc-POU3F3 in ESCC.
Methods: We performed quantitative real-time polymerase chain reaction to assess lnc-POU3F3 expression pattern in ESCC blood samples from 32 patients with ESCC and age- and sex-matched healthy controls.
Results: Lnc-POU3F3 was significantly overexpressed in ESCC blood samples compared to normal samples. In addition, this overexpression had a significant correlation with family history (P=0.03) and TNM stage (P=0.02).
Conclusion: According to the findings of the present study, lnc-POU3F3 may be used as a diagnostic biomarker for ESCC. However, studies with a larger sample size should be carried out to confirm this finding.
Keywords: Esophageal cancer, ESCC, lncRNA, lnc-POU3F3
     
Article Type: Research | Subject: Medicine
Received: 2018/12/28 | Accepted: 2018/12/28 | Published: 2018/12/28
Add your comments about this article
Your username or Email:

CAPTCHA code


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Rahimnia H, Moradi A, Javid N, Fateri Y, Bahramian S, Roohinejad Z, et al . Overexpression of Long Non-Coding RNA POU3F3 in Esophageal Squamous Cell Carcinoma is Associated with TNM Stage and Family History. jcbr. 2018; 2 (4)
URL: http://jcbr.goums.ac.ir/article-1-168-en.html


Volume 2, Issue 4 (Journal of Clinical and Basic Research(JCBR) 2018) Back to browse issues page
Journal of Clinical and Basic Research Journal of Clinical and Basic Research
Persian site map - English site map - Created in 0.05 seconds with 31 queries by YEKTAWEB 3815