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:: Volume 2, Issue 4 (Journal of Clinical and Basic Research(JCBR) 2018) ::
jcbr 2018, 2(4): 48-53 Back to browse issues page
Overexpression of Long Non-Coding RNA POU3F3 in Esophageal Squamous Cell Carcinoma is Associated with TNM Stage and Family History
Halime Rahimnia1, Abdolvahab Moradi2, Naemeh Javid2, Yasaman Fateri1, Shabbou Bahramian2, Zahra Roohinejad2, Hossein Sabouri3, Eisa Jorjani *1
1- Department of Biology, Gonbad Kavous University, Gonbad Kavous, Iran
2- Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran
3- *Correspondence: Eisa Jorjani, Department of Biology, Gonbad Kavous Univers
Abstract:   (387 Views)
Background and objectives: Esophageal cancer (EC) is the second most common gastrointestinal cancer, and esophageal squamous cell carcinoma (ESCC) is the dominant type of EC in Iran. One of the most important challenges in cancer management is the early diagnosis. As tumor suppressors or oncogenes, long non-coding RNAs (lncRNAs) play a vital role in tumor initiation, progression and metastasis. Recent studies have reported dysregulated expression of lncRNAs in different tumor tissues including ESCC, which may indicate its prognostic or diagnostic potential in ESCC. In this study, we investigated expression pattern of lnc-POU3F3 in ESCC.
Methods: We performed quantitative real-time polymerase chain reaction to assess lnc-POU3F3 expression pattern in ESCC blood samples from 32 patients with ESCC and age- and sex-matched healthy controls.
Results: Lnc-POU3F3 was significantly overexpressed in ESCC blood samples compared to normal samples. In addition, this overexpression had a significant correlation with family history (P=0.03) and TNM stage (P=0.02).
Conclusion: According to the findings of the present study, lnc-POU3F3 may be used as a diagnostic biomarker for ESCC. However, studies with a larger sample size should be carried out to confirm this finding.
Keywords: Esophageal cancer, ESCC, lncRNA, lnc-POU3F3
Full-Text [PDF 496 kb]   (111 Downloads)    
Article Type: Research | Subject: Medicine
Received: 2018/12/28 | Accepted: 2018/12/28 | Published: 2018/12/28
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Rahimnia H, Moradi A, Javid N, Fateri Y, Bahramian S, Roohinejad Z, et al . Overexpression of Long Non-Coding RNA POU3F3 in Esophageal Squamous Cell Carcinoma is Associated with TNM Stage and Family History. jcbr. 2018; 2 (4) :48-53
URL: http://jcbr.goums.ac.ir/article-1-168-en.html


Volume 2, Issue 4 (Journal of Clinical and Basic Research(JCBR) 2018) Back to browse issues page
Journal of Clinical and Basic Research Journal of Clinical and Basic Research
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