Volume 8, Issue 2 (Journal of Clinical and Basic Research (JCBR) 2024)
jcbr 2024, 8(2): 17-19 |
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Mahfouz N N, Abd El-Shaheed A, Sallam S F, Moustafa R S I, El-Zayat S R, Sibaii H. Obesity induced renal injury: Could It be detected early?. jcbr 2024; 8 (2) :17-19
URL: http://jcbr.goums.ac.ir/article-1-408-en.html
URL: http://jcbr.goums.ac.ir/article-1-408-en.html
Nermine Nabil Mahfouz1 
, Azza Abd El-Shaheed1 , Sara Fawzy Sallam * 2, Rehab Selim Ismail Moustafa1 , Salwa Refaat El-Zayat3 , Hiba Sibaii3
, Azza Abd El-Shaheed1 , Sara Fawzy Sallam * 2, Rehab Selim Ismail Moustafa1 , Salwa Refaat El-Zayat3 , Hiba Sibaii3
1- Department of Child Health, Medical Research and Clinical Studies Institute, Medical Research Centre of Excellence (MRCE), National Research Centre, Cairo, Egypt
2- Department of Child Health, Medical Research and Clinical Studies Institute, Medical Research Centre of Excellence (MRCE), National Research Centre, Cairo, Egypt ,lara26sara@gmail.com
3- Physiology Department, Medical Research and Clinical Studies Institute, Medical Research Centre of Excellence (MRCE), National Research Centre, Cairo, Egypt
2- Department of Child Health, Medical Research and Clinical Studies Institute, Medical Research Centre of Excellence (MRCE), National Research Centre, Cairo, Egypt ,
3- Physiology Department, Medical Research and Clinical Studies Institute, Medical Research Centre of Excellence (MRCE), National Research Centre, Cairo, Egypt
Abstract: (396 Views)
Background: The onset of obesity-associated renal injury is insidious and asymptomatic. Therefore, finding an early marker will be extremely useful in its detection. Kidney injury molecule-1 (KIM-1) can be evaluated as an early marker for renal injury in obese children.
Methods: This case control study involved two groups: a case group of 45 Egyptian overweight/obese children and a control group of 45 non-obese peers. Anthropometry and blood pressure were measured in both groups. Additionally, KIM-1 and serum creatinine levels were assessed.
Results: Compared to the control group, the case group showed a significantly higher systolic (P-value 0.000) and diastolic (P-value 0.002) blood pressure. A significantly higher serum creatinine (P=0.007) and KIM-1 (P=0.001) were also found.
Conclusion: It is inferred that obesity impacts renal hemodynamics early in childhood. Thus, identifying a screening marker like KIM-1 is useful for the early diagnosis of renal injury.
Methods: This case control study involved two groups: a case group of 45 Egyptian overweight/obese children and a control group of 45 non-obese peers. Anthropometry and blood pressure were measured in both groups. Additionally, KIM-1 and serum creatinine levels were assessed.
Results: Compared to the control group, the case group showed a significantly higher systolic (P-value 0.000) and diastolic (P-value 0.002) blood pressure. A significantly higher serum creatinine (P=0.007) and KIM-1 (P=0.001) were also found.
Conclusion: It is inferred that obesity impacts renal hemodynamics early in childhood. Thus, identifying a screening marker like KIM-1 is useful for the early diagnosis of renal injury.
Article Type: Research |
Subject:
Pediatrics
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