Volume 7, Issue 3 ( Journal of Clinical and Basic Research (JCBR) 2023)                   jcbr 2023, 7(3): 22-24 | Back to browse issues page

XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Inkalagi V, Priyanka K. Study to evaluate the haematological profile of patients with chronic liver disease. jcbr 2023; 7 (3) :22-24
URL: http://jcbr.goums.ac.ir/article-1-402-en.html
1- Department of General Medicine, Al Ameen Medical College, Bijapur, Karnataka 586108
2- Department of Obstetrics and Gynaecology, Belgaum Institute of Medical Sciences, Sadashiv Nagar, Belagavi, Karnataka 590019
Abstract:   (433 Views)
Background: The liver plays an important role in homeostasis. Chronic liver diseases (CLDs), including cirrhosis, hepatic failure, jaundice, and portal hypertension, may affect hemopoiesis. The abnormalities in red blood cells (RBC), white blood cells (WBC), and platelet functions in patients with CLD are well-documented. It is thus important to detect and manage these abnormalities to reduce the overall morbidity and mortality of patients with CLD.
Aims: The study was conducted to assess the hematological abnormalities and hemostatic derangements and the nature of hematological abnormalities to reduce morbidity. Broadly, the hematological abnormalities are viewed under abnormalities in RBCs, WBCs, platelets, and the coagulation profile.
Methods: This was a prospective study conducted for 2 years at the Department of General Medicine, Al Ameen Medical College, Bijapur, Karnataka. A total of 150 patients with CLD were included and analyzed for hematological dysfunction.
Results: Severe anemia (<6g/dL) was noted in 9.33% of the cases; 22% of the cases had 6.1 to 8 g/dL Hb (hemoglobin) levels; 38% cases showed Hb of 8.1 to 10 g/dL; and >10 g/dL HB was noted in 45% cases. The majority showed normocytic normochromic anemia on peripheral smear examination, i.e., 56%. Macrocytic anemia was noted in 25.3% of cases. Microcytic hypochromic anemia was found in 38% of the cases. Only 4.67% showed dimorphic anemia. Besides, 66.6% of cases had a WBC count of 4000-11000/cumm, 26.6% had 2000-4000/cumm, 6.67% had < 2000/cumm, and 59% cases had >1 .0 lakh /cumm. In 66.67% of cases,1 lakh – 50000 (mild thrombocytopenia) was noted in 25.3% of cases. Moreover, 6.6% had moderate thrombocytopenia, and 1.3% < 20000 /cumm (severe thrombocytopenia).
Conclusion: This study demonstrated that all the patients presented with signs of CLD must be thoroughly evaluated for their complete blood profile to detect hematological abnormalities and should be monitored for any complications. Early initiation of treatment can decrease the overall mortality in these patients.
Full-Text [PDF 359 kb]   (255 Downloads)    
Article Type: Research | Subject: Oncology

References
1. Poynard T, Mathurin P, Lai CL, Guyader D, Poupon R, Tainturier MH, et al. A comparison of fibrosis progression in chronic liver diseases. J Hepatol. 2003;38(3):257-65. [View at Publisher] [DOI] [PMID] [Google Scholar]
2. Allison MG, Shanholtz CB, Sachdeva A. Hematological issues in liver disease. Crit Care Clin. 2016;32(3):385-96. [View at Publisher] [DOI] [PMID] [Google Scholar]
3. Khare S, Garg VK, Jain H, Jatav O. To study hematological profile in patients of chronic liver disease. Int J Multidiscip Res Dev. 2015;2(8):378-81. [View at Publisher] [Google Scholar]
4. Camaschella C. Iron-deficiency anemia. N Engl J Med. 2015;373(5):485-6. [View at Publisher] [DOI] [PMID] [Google Scholar]
5. Van Vlierbergh H, Delanghe JR, De Vos M, Leroux-Roel G; Steering Committee B. Factors influencing ribavirin-induced hemolysis. J Hepatol. 2001;34(6):911-6. [View at Publisher] [DOI] [PMID] [Google Scholar]
6. Selvamani S, Thomas S. Evaluation of haematological abnormalities in decompensated chronic liver disease patients. IOSR-JDMS. 2017;16(8):16-21. [View at Publisher] [DOI] [Google Scholar]
7. Behera BP, Dash M. An observational study of clinical and hematological profile of cirrhosis of liver. Asian J Pharm Clin Res. 2020;13(4):149-52. [View at Publisher] [DOI] [Google Scholar]
8. Chandra Jha S, Kumar Singh J, Kumar A. Hematological Abnormalities in Chronic Liver Disease: A Retrospective Study in North Bihar. J Medic Sci Clin Res. 2019;07(05):779-84. [View at Publisher] [DOI] [Google Scholar]
9. Khare S, Kumar Garg V, Kumar Jain H, Jatav O. To study haematological profile in patients of chronic liver disease. Int J Multidisciplin Res Dev. 2015;2(8):378-81. [View at Publisher] [Google Scholar]
10. Kaur J, Kaur N, Kaur J, Kaur Layal N, Kaur G. A Study on Haematological Manifestations in Patients with Chronic Liver Disease in a Tertiary Care Hospital of North. J Evid Based Med Healthc. 2021;8(25):2222-8. [View at Publisher] [DOI] [Google Scholar]
11. Solomen RT, Aravind A, Caroline Selvi K, Balamurali R, Ramkumar G, Muthukumuran K, et al. A Study on Hematological Abnormalities in Chronic Liver Diseases. IOSR Journal of Dental and Medical Sciences (IOSR-JDMS). 2017;16(6):38-44. [View at Publisher] [DOI] [Google Scholar]
12. Awasthi VR, Deshpande JJ, Sujata P. Study of hematological and biochemical profile in patients with alcoholic liver disease in rural Maharashtra. Innov Pharm Pharmacother. 2019;07(34):27-30. [View at Publisher] [Google Scholar]

Add your comments about this article : Your username or Email:
CAPTCHA

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Journal of Clinical and Basic Research

Designed & Developed by : Yektaweb

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0).