Volume 6, Issue 2 (Journal of Clinical and Basic Research (JCBR) 2022)                   jcbr 2022, 6(2): 31-35 | Back to browse issues page

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Sahu D, Nayak S, Mohanty N, panda B. Acute Pancreatitis in the Setting of Vaso-Occlusive Sickle Cell Crisis: A Rare Differential Diagnosis. jcbr 2022; 6 (2) :31-35
URL: http://jcbr.goums.ac.ir/article-1-359-en.html
1- PG Department of Medicine, SCBMedical College, Cuttack, India
2- PG Department of Medicine, SCBMedical College, Cuttack, India , drnihar123@yahoo.com
Abstract:   (642 Views)
Sickle cell disease(SCD) is a hemoglobinopathy characterized by chronic hemolyticanemia and vaso-occlusive painful crisis. The vascular occlusion in SCD is a complex process that is responsible for most clinical manifestations of the disease. Abdominal pain is an important component of vaso-occlusive painful crisis and may mimic diseases, such as acute appendicitis and cholecystitis. Acute pancreatitis is rarely encountered as a cause of abdominal pain in patients with SCD. Gallstones and alcohol abuse account for the majority of the cases of acute pancreatitis. Pancreatic ischemia is an uncommon but established cause of pancreatitis associated with connective tissue diseases, vasculitis, and shock. In SCD, the deformed red blood cellsresulting from deoxygenation during stress, infection or dehydration, cause vaso-occlusion, tissue ischemia, and infarction. We present a case of SCDpresenting as acute pancreatitis apparently due to microvascular occlusion and ischemic injury to the pancreas. The patient responded to conservative management. Our case will help to always keep in mind and consider acute pancreatitis as a differential diagnosis in patients with SCD presenting with abdominal pain.
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Article Type: Case report | Subject: Medicine
Received: 2022/05/22 | Accepted: 2022/07/3 | Published: 2022/07/12

1. Wang WC, Lukens JN. Sickle cell anaemia and other sickling syndromes. In: Lee RG, Foerster J, Lukens J, et al., editors. Wintrobe's clinical haematology. Baltimore, MD: Williams & Wilkins; 1999.p 1346-1397.
2. Bunn HF. Pathogenesis and treatment of sickle cell disease. New England Journal of Medicine. 1997 Sep 11;337(11):762-9. [View at Publisher] [DOI] [PMID] [Google Scholar]
3. Kumar A, Posner G, Marsh F, Bellvue R, Dosik H. Acute pancreatitis in sickle cell crisis. Journal of the National Medical Association. 1989 Jan;81(1):91. [PubMed] [Google Scholar]
4. Sheehan AG, Machida H, Butzner JD. Acute pancreatitis in a child with sickle cell anemia. Journal of the National Medical Association. 1993 Jan;85(1):70. [PubMed] [Google Scholar]
5. Yadav D, Lowenfels AB. The epidemiology of pancreatitis and pancreatic cancer. Gastroenterology. 2013 May 1;144(6):1252-61. [View at Publisher] [DOI] [PMID] [PMCID] [Google Scholar]
6. Ebert EC, Nagar M, Hagspiel KD. Gastrointestinal and hepatic complications of sickle cell disease. Clinical gastroenterology and hepatology. 2010 Jun 1;8(6):483-9. [View at Publisher] [DOI] [PMID] [Google Scholar]
7. Ahmed S, Siddiqui AK, Siddiqui RK, et al.: Acute pancreatitis during sickle cell vaso ‐ occlusive painful crisis. Am J Hematol. 2003, 73:190-3. 10.1002/ajh.10344 [View at Publisher] [DOI] [PMID] [Google Scholar]
8. Dhiman RK, Yusif RA, Nabar UJ, Albaqali A. Gastrointestinal: ischemic enteritis and sickle cell disease. Journal of gastroenterology and hepatology. 2004 Nov;19(11):1318-. [View at Publisher] [DOI] [PMID] [Google Scholar]
9. Ziegler DW, Long JA, Philippart AI, Klein MD. Pancreatitis in childhood. Experience with 49 patients. Annals of surgery. 1988 Mar;207(3):257. [DOI] [PMID] [PMCID] [Google Scholar]
10. Topazian M, Gorelick FS. Acute pancreatitis. In: Yamada T, Alpers DH, Laine L, et al., editors. Textbook of gastroenterology. Baltimore, MD: Lippincott Williams & Wilkins; 1999. p 2121-2150.
11. Agarwal N, Pitchumoni CS, Sivaprasad AV. Evaluating test for acute pancreatitis. Am J Gastroenterol 1990;85:356-366. [Google Scholar]
12. Larvin M, Chalmers AG, McMahon MJ. Dynamic contrast enhanced computed tomography: a precise technique for identifying and localising pancreatic necrosis. British Medical Journal. 1990 Jun 2;300(6737):1425-8. [View at Publisher] [DOI] [PMID] [PMCID] [Google Scholar]
13. Hasan B, Asif T, Braun C, Bahaj W, Dosokey E, Pauly RR. Pancreatitis in the setting of vaso-occlusive sickle cell crisis: a rare encounter. Cureus. 2017 Apr 25;9(4). [View at Publisher] [DOI] [Google Scholar]

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