Volume 5, Issue 2 (Journal of Clinical and Basic Research (JCBR) 2021)                   jcbr 2021, 5(2): 17-25 | Back to browse issues page

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Parhiz J, Rahafard S, Sharifi S, Kompani F. Comparison of Co-trimoxazole and Cephalexin Efficacy in Preventing Urinary Tract Infection among Children. jcbr. 2021; 5 (2) :17-25
URL: http://jcbr.goums.ac.ir/article-1-309-en.html
1- Neonatal and Children's Health Research Center, Golestan University of Medical Sciences, Gorgan, Iran
Abstract:   (801 Views)
Background and objectives: Diagnosis and treatment of urinary tract infection (UTI) in children before kidney damage is necessary. The purpose of this study was to compare efficacy of co-trimoxazole and cephalexin in the prevention of recurrent UTI in children.
Methods: The study was performed on 100 children aged three months to 14 years who were referred to the Taleghani Pediatric Hospital in Gorgan (Iran) during 2016. The subjects had a history of UTI and required antibiotic prophylaxis to prevent UTI. They were divided into two groups of co-trimoxazole and cephalexin. Data were analyzed using SPSS (version 18) and at significance level of 0.05.
Results: Recurrent UTI was observed in eight children (16.0%) taking cephalexin and in six children (12.0%) receiving co-trimoxazole (p=0.56). Urine culture examination revealed Escherichia coli as the causative agent of UTI in six cases (75 %) receiving cephalexin and in five cases (83.3%) receiving co-trimoxazole (p=0.70). It should be noted that unilateral moderate hydronephrosis was the most frequent anomaly (n=26) in the study groups.
Conclusion: According to the results of the present study, both cephalexin and co-trimoxazole have similar efficacy in the prevention of UTI among children.
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Article Type: Research | Subject: Basic medical sciences
Received: 2021/04/1 | Accepted: 2021/05/17 | Published: 2021/05/31

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