Volume 5, Issue 1 ( Journal of Clinical and Basic Research (JCBR) 2021)                   jcbr 2021, 5(1): 33-38 | Back to browse issues page

XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ebneghasem R, Besharat S, Khodabakhshi B, Golsha R, Shirzad-Aski H, Sohrabi A, et al . Serum Level of Anti-Hepatitis B Surface Antigen 18 Years after Vaccination in Students of Golestan University of Medical Sciences, Iran. jcbr. 2021; 5 (1) :33-38
URL: http://jcbr.goums.ac.ir/article-1-300-en.html
1- Infectious Diseases Research Center; Golestan University of Medical Sciences, Gorgan, Iran
2- Golestan Research Center of Gastroenterology and Hepatology (GRCGH); Golestan University of Medical Sciences, Gorgan, Iran.
3- Department of Electrical and Computer Engineering, National University of Singapore, Singapore
4- Biomedical engineering department, National University of Singapore, Singapore
Abstract:   (224 Views)

ABSTRACT

Background and objectives: Hepatitis B virus (HBV) is one of the most common viral infections and amongst the top health priorities worldwide. Due to frequent exposure, medical students are at high risk of developing HBV infection. This study was conducted to evaluate serum level of anti-HBV surface antigen (HBsAg) 18 years after HBV vaccination in students of the Golestan University of Medical Sciences (Gorgan, Iran).

Methods: In this cross-sectional study, 241 students (18-20 years old, 137 women) who had been vaccinated at infancy were enrolled. After recording demographic data, blood sample was taken to measure HBsAg, HBs anti-body (HBs-Ab) and HBc antibody (total HBcAb) using commercial enzyme-linked immunosorbent assay kits. Data were analyzed by the chi-square test using SPSS 16 and at significance of 0.05.

Results: HBsAb titer of less than 10 mlU/ml was found in 167 (69.3%) participants (89 females and 78 males). Positive HBsAg and anti-HBcAb were not observed in the subjects. There was no significant relationship between antibody titer and sex, body mass index, place of residence and ethnicity (P>0.05).

Conclusion: The high number of medical students with seronegative antibody levels is a cause for concern. In this regard, more attention should be paid to high risk students in medical school of the Golestan Province.

Full-Text [PDF 321 kb]   (40 Downloads)    
Article Type: Research | Subject: Basic medical sciences
Received: 2021/04/20 | Accepted: 2021/01/21 | Published: 2021/01/21

References
1. Asghari Estiar M, Moaddab R, Esmaeelnasab N, Rafi A. Immunogenicity of Hepatitis B Vaccine among Medical Staff of Shahid Madani Hospital of Tabriz, Iran. J Fasa Univ Med Sci. 2014; 4(2): 154-160. [In Persian]
2. Alavian SM, Hajarizadeh B, Ahmadzad-Asl M, Kabir A, Bagheri-Lankarani K. Hepatitis BVirus infection in Iran: A systematic review. Hepatitis monthly. 2008 Oct 1; 8.
3. Alavian SM, Fallahian F, Bagheri Lankarani K. The Changing Epidemiology of Viral Hepatitis B in Iran. J Gastrointestin Liver Dis. 2007; 16 (4): 403-406.
4. Berati M, Ishaqi M, Borji S. The level of knowledge of Mashkin-dasht students in Karaj about the ways of transmission and prevention of hepatitis B. Journal of Iran University of Medical Sciences. 2005; 12(46): 249-253.
5. Mohammad Nejad E, Ehsani SR, Rahmani H, Abootalebi Gh, Ranjbaran S, Zebardast J. Evaluation of Hepatitis B Virus Antibody and Effective Factors on its Changes in Nurses. JHC. 2012; 14(1 And 2): 36-43. [In Persian]
6. Mostafa Salehi-Vaziri, Farzin Sadeghi, Amir Almasi Hashiani, Mohammad Gholami Fesharaki, Seyed Moayed Alavian. Hepatitis B Virus Infection in the General Population of Iran: An Updated Systematic Review and Meta-Analysis. Hepat Mon. 2016; 16 (4): e35577. [DOI:10.5812/hepatmon.35577]
7. Taghavi Ardakani A, Soltani B Sharif MR, Moosavi GhA, Khademian M. Evaluation of serum hepatitis B antibody level in vaccinated children after 14 years in Kashan, Iran. Journal of Gorgan University of Medical Sciences. 2012; 14(3).
8. Hepatitis B. http://www.who.int/news-room/fact-sheets/detail/hepatitis-B.
9. Jafarzadeh A, Montazerifar SJ. Persistence of anti-HBs antibody and immunological memory in children vaccinated with hepatitis B vaccine at birth. J Ayub Med Coll Abbottabad. 2006; 18:4-6.
10. Nooshiravanpour P, Ramazenkhani A, Gashani M, Khodakarim S, Hatami H. Immunity against hepatitis-B among freshman students at Shahid Beheshti University of Medical Sciences, academic year 2012-2013. Research in Medicine. 2014; 38 (3):176-180.
11. Alavian SM, Tabatabaei SV, Nourizad S, MansoriF , Khademi N and et al. Seroepid- emiology of HBV infectionin Kermanshah- west of Iran; a population based study. Jundishapour J Microbiol. 2012; 5 (4): 564-569. [DOI:10.5812/jjm.4156]
12. Shamsizadeh A, Makvandi M, Shoshtari G. Prevalence of anti-hepatitis B surface antibody among children in Ahvaz, Iran, five years after vaccination. JJM. (2011); 4(1): 49-54.
13. Norouzirad R; Shakurnia AH; Assarehzadegan MA; Serajian A; Khabazkhoob M. Serum Levels of Anti-Hepatitis B Surface Antibody Among Vaccinated Population Aged 1 to 18 Years in Ahvaz City Southwest of Iran. Hepat Mon. 2014; 14(1). [DOI:10.5812/hepatmon.13625]
14. Lu CY, Chiang BL, Chi WK, Chang MH, Ni YH, Hsu HM, et al. Waning immunity to plasma-derived hepatitis B vaccine and the need for boosters 15 years after neonatal vaccination. Hepatology. 2004; 40:1415-20. [DOI:10.1002/hep.20490]
15. Amini S, Andalibi S, Mahmoodi M. Anti-HBs response and its protective effect in children and adults receiving hepatitis B recombinant vaccine in Tehran. Iranian J Med Sci. 2002; 27: 101-105.
16. Darvish Moghaddam S, Zahedi MJ, Yazdani R. Persistence of immune response after hepatitis vaccination in medical students and residents. Arch Iranian Med. 2004; 7:37-40.
17. Mahallawi W. Persistence of hepatitis B surface antibody and immune memory to hepatitis B vaccine among medical college students in Madinah. Ann Saudi Med. 2018; 38(6): 413-419. [DOI:10.5144/0256-4947.2018.413]
18. Norrozi M, Azami A, Sarraf-neduad A, Chitsaz H, Rahmati. Persistence of anti-HBs antibody and immune memory to hepatitis B vaccine, 18 years after infantile vaccination in students of Tehran University. Research on Medicine; 2016; 40(1):36-41.
19. Kazemi A, Koosha A, Rafizadeh B, Mousavinasab N, Mahram M. Serum level of anti-hepatitis B surface antigen 6-8 years after hepatitis B vaccination at birth. East Mediterr Health J. 2008; 14:960-65.12.
20. Izadpanah A, Mashreghy Moghadam H, Ziaee M, Foadaldini M, Ebadian F. Anti HBs level in nursing staff of Birjand University of Medical Sciences. Journal of Birjand University of Medical Sciences. 2008; 15:80-85.
21. Rostami H, Farmani S, Mirzaee A, Ghorbanzadeh R. Evaluating the rate of immune response for hepatitis b vaccine in high risk personel. J Urmia Nurs Midwifery Fac. 2008; 6 (4):179-182. [In Persian]
22. Baba Mahmoodi F. Evaluation of Hepatitis B Antibody (HBS) Levels in Nursing Staff of Gaemshahr Razi Hospital and its Variation With Duration Of Immunity Post HB Vaccination. J Mazandaran Univ Med Sci. 2000; 10 (27):48-53.[In Persian]
23. Mansour-Ghanaei F, Fallah MS, Jafarshad R, Joukar F, Arami A, Ale-esmaeil F, et al. The Immunologic Response to anti-hepatitis B vaccination among medical students of Guilan University of Medical Sciences, Guilan, Iran.Hepatitis Monthly 2006; 6: 63-66.
24. Davoud-zadeh M, Rajabi poor F, Shafi-zadeh F, Ghorbani vagheie A. Determination of HbsAb level in vaccinized medical students of Lorestan University of Medical Sciences in autumn 2004. Yafte. 2005; 6 (4):57-61. [In Persian]
25. Shin BM, Jeong KW.Distribution of anti-HBs levels in Korean adults. Yonsei Medical Journal.2000; 41(1): 40-8. [DOI:10.3349/ymj.2000.41.1.40]
26. Funderburke PL, Spencer L. Hepatitis B immunity in high risk health care workers. Seven Years post vaccination. American Association of Occupational Health Nurses Journal.2000; 48(7):325-30. [DOI:10.1177/216507990004800703]
27. Hajibagheri K, Kanani Sh , Moradi Gh , Yousefinejad V. Response to Hepatitis B Vaccination among Health CcareWorkers .IJIDTM Journal.2008;13(40).[In Persian]
28. Shahri L, Ali Asghari F,et al. Evaluation of immune response of hepatitis B vaccine in female students of North Khorasan University of Medical Sciences. Journal of North Khorasan University of Medical Sciences. 2013; 5: 1057-106. [DOI:10.29252/jnkums.5.5.S5.1057]

Add your comments about this article : Your username or Email:
CAPTCHA

© 2021 CC BY-NC 4.0 | Journal of Clinical and Basic Research

Designed & Developed by : Yektaweb

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0).