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Saifi A, Ahmadi A, Mansourian A. Hypothyroidism in Elderly Population: A Review. jcbr. 2017; 1 (1) :47-53
URL: http://jcbr.goums.ac.ir/article-1-28-en.html
Abstract:   (2716 Views)


Many metabolic disorders originate from thyroid disorders, particularly from hypothyroidism. Hypothyroidism commonly occurs in elderly subjects, particularly in women. Subclinical form of hypothyroidism can be diagnosed via laboratory testing. It is crucial to check thyroid hormone profile in elderly subjects. Subclinical hypothyroidism can eventually lead to overt hypothyroidism if left untreated. Treatment of subclinical hypothyroidism could be helpful in preventing the complications of hypothyroidism, particularly among the elderly population. The main aim of this review was to investigate subclinical hypothyroidism among elderly subjects.

KEYWORDS: Hypothyroidism, Subclinical hypothyroidism, Elderly

Full-Text [PDF 294 kb]   (1053 Downloads)    
Article Type: Research | Subject: Statistics and epidemiology
Received: 2017/02/13 | Accepted: 2017/04/5 | Published: 2017/05/15

1. Mansourian AR, Ahmadi AR. Correlation between inverse age and serum thyroxine level among children and adolescents. J. Clin. Diagn.Res. 2010;4:3196-3200.
2. Mansourian AR. A review on hyperthyroidism.Thyrotoxicosis under surveillance. Pak. J. Biol. Sci. 2010;13:1066-1076. [DOI:10.3923/pjbs.2010.1066.1076]
3. Mansourian AR. The state of serum lipids profiles in sub-clinical hypothyroidism: A review of the literature. Pak. J. Biol. Sci. 2010;13:556-562. [DOI:10.3923/pjbs.2010.556.562]
4. Mansourian AR. Thyroid function tests during first-trimester of pregnancy: A review of literature. Pak. J. Biol. Sci. 2010;13:664-673. [DOI:10.3923/pjbs.2010.664.673]
5. Mansourian AR. The immune system which adversely alter thyroid functions: A review on the concept of autoimmunity. Pak. J. Biol. Sci. 2010;13:765-774. [DOI:10.3923/pjbs.2010.765.774]
6. Mansourian AR. A review on post-puberty Hypothyroidism: A glance at myxedema. Pak. J. Biol. Sci. 2010;13:866-876. [DOI:10.3923/pjbs.2010.866.876]
7. Mansourian AR. Metabolic pathways of tetraidothyronine and triidothyronine production by thyroid gland: A review of articles. Pak. J. Biol. Sci. 2011;14:1-12. [DOI:10.3923/pjbs.2011.1.12]
8. Mansourian AR. Central dogma in thyroid dysfunction: A review on structure modification of TSHR as a cornerstone for thyroid abnormalities. Pak. J. Biol. Sci. 2011;14:170-181. [DOI:10.3923/pjbs.2011.170.181]
9. Mansourian AR. Abnormal serum thyroid hormones concentration with healthy functional gland: A review on the metabolic role of thyroid hormones transporter proteins. Pak. J. Biol. Sci. 2011;14:313-326. [DOI:10.3923/pjbs.2011.313.326]
10. Mansourian AR. A review on the metabolic disorders of iodine deficiency. Pak. J. Biol. Sci. 2011;14:412-424. [DOI:10.3923/pjbs.2011.412.424]
11. Mansourian AR. A review of literature on the adverse effects of hyperthyroidism on the heart functional behavior. Pak. J. Biol. Sci. 2012;15:164-176. [DOI:10.3923/pjbs.2012.164.176]
12. Mansourian, A.R., A literature review on the adverse effect of hypothyroism on kidney function. Pak. J. Biol. Sci. 2012;15:709-719. [DOI:10.3923/pjbs.2012.709.719]
13. Mansourian AR. A review on cardiovascular diseases originated from subclinical hypothyroidism. Pak. J. Biol. Sci. 2012;15:58-67. [DOI:10.3923/pjbs.2012.58.67]
14. Mansourian AR. Female reproduction physiology adversely manipulated by thyroid disorders: A review of literature. Pak. J. Biol. Sci. 2013;16:112-120. [DOI:10.3923/pjbs.2013.112.120]
15. Mansourian AR, Sifi A and Mansourian HR. Serum thyroxin level during the first-trimester of pregnancy. J. Clin. Diagn. Res. 2011;5:733-736.
16. Mansourian AR, Ahmadi AR, Saifi A and Bakhshandehnosrat S. The children reference range of thyroid hormones in Northern Iran. Pak. J. Biol. Sci. 2010;13:862-865. [DOI:10.3923/pjbs.2010.862.865]
17. Mansourian AR, Ahmadi AR, Mansourian HA. Saifi A, Marjani A, Veghari GR and Ghaemi E. Maternal thyroid stimulating hormone level during the first trimester of pregnancy at the South-East of the caspian sea in Iran. J. Clin. Diagn. Res. 2010;4:2472-2477.
18. Mansourian, AR, E. Ghaemi, Ahmadi AR, Marjani A, Saifi A and Bakhshandehnosrat S., Serum lipid level alterations in subclinical hypothyroid patients in Gorgan (South East of Caspian Sea).Chinese Clin. Med. 2008;3:206-210.
19. Mansourian AR, Ghaemi EO, Ahmadi AR, Saifi A, Moradi AV and Bakhshandeh-Nosrat S. A survey of urinary iodine concentration in South-East of Caspian Sea in Northern, Iran. Pak. J. Biol. Sci. 2007;10:2166-2171. [DOI:10.3923/pjbs.2007.2166.2171]
20. Tunbridge WM, Evered DC, Hall R, et al. The spectrum of thyroid disease in a community: The Whickham Survey. ClinEndocrinol. 1977;7:481-493. [DOI:10.1111/j.1365-2265.1977.tb01340.x]
21. Vanderpump MP, TunbridgeWM, French JM, et al. The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey. ClinEndocrinol. 1995;43:55-68. [DOI:10.1111/j.1365-2265.1995.tb01894.x]
22. Van den Beld AW, Visser TJ, Feelders RA, Grobbee DE, Lamberts SW. Thyroid hormone concentrations, disease, physical function, and mortality in elderly men. J ClinEndocrinolMetab. 2005;90:6403-6409. [DOI:10.1210/jc.2005-0872]
23. Glenn GC. Practice parameter on laboratory panel testing for screening and case finding in asymptomatic adults. Laboratory Testing Task Force of the College of the American Pathologists. Arch Pathol Lab Med. 1996;120:929-943.
24. Ladenson PW, Singer PA, Ain KB, et al. American Thyroid Association guidelines for detection of thyroid dysfunction. Arch Intern Med. 2000;160:1573-1576. [DOI:10.1001/archinte.160.11.1573]
25. Bjoro T, Homen J, Kruger O, et al. Prevalence of thyroid disease, thyroid dysfunction and thyroid peroxidase antibodies in a large, unselected population. The Health Study of Nord-Trondelag (HUNT) Eur J Endocrinol. 2000;143:639-647. [DOI:10.1530/eje.0.1430639]
26. Biondi B, Cooper DS. The clinical significance of subclinical thyroid dysfunction. Endocrine Reviews. 2008; 29:76–131. [DOI:10.1210/er.2006-0043]
27. Andersen S, Pedersen KM, Bruun NH, Laurberg P. Narrow individual variations in serum T(4) and T(3) in normal subjects: a clue to understanding of subclinical thyroid disease. J ClinEndocrinolMetab. 2002; 87:1068–1072. [DOI:10.1210/jcem.87.3.8165]
28. Hansen PS, Brix TH, Sorensen TI, Kyvik KO, Hegedus L. Major genetic influence on the regulation of the pituitary-thyroid axis: a study of healthy Danish twins. J ClinEndocrinolMetab. 2004;89:1181-1187. [DOI:10.1210/jc.2003-031641]
29. Hollowell J, Staehling NW, Flanders D, et al. Serum TSH, T4, and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III) J, Clin Endocrinol Metab. 2002;87: 489-499. [DOI:10.1210/jcem.87.2.8182]
30. Sawin CT, Castelli WP, Hershman JM, McNamara P, Bacharach P. The aging thyroid.Thyroid deficiency in the Framingham Study. Arch Intern Med. 1985;145.1386-1388.
31. Magri F, Muzzoni L, Cravello M, et al. Thyroid function in physiological aging and in Centenarians: possible relationships with some nutritional markers. Metabolism. 2002;51.105-109.
32. Mariotti S, Franceschi C, Cossarizza A, Pinchera A. The aging thyroid.Endocr Rev. 1995;16.686-715.
33. Mitrou P, Raptis SA, Dimitriadis G. Thyroid disease in older people. Maturitas. 2011;70,5-9. [DOI:10.1016/j.maturitas.2011.05.016]
34. Danforth E, Jr, Burger AG. The impact of nutrition on thyroid hormone physiology and action.Annu Rev Nutr. 1989; 9:201-227. [DOI:10.1146/annurev.nu.09.070189.001221]
35. American College of Physicians.Clinical guideline, part 1.Screening for thyroid diseases. Ann Intern Med. 1998; 129.141-143.
36. American College of Physicians.Clinical guideline, part 2.Screening for thyroid diseases. Ann Intern Med. 1998; 129.144-158.
37. Gharib H, Tuttle RM, Baskin HJ, Fish LH, Singer PA, McDermott MT. Consensus Statement: Subclinical thyroid dysfunction: a joint statement on management from the American Association of Clinical Endocrinologists, the American Thyroid Association, and The Endocrine Society. Thyroid. 2005;5: 24-28. [DOI:10.1089/thy.2005.15.24]
38. American Association of Clinical Endocrinologists. American Endocrinologists medical guidelines for clinical practice for the evaluation and treatment of hyperthyroidism and hypothyroidism.EndocrPract. 2002;8;457-469. [DOI:10.4158/1934-2403-8.6.457]
39. American Academy of Family Physicians.Summary of Policy Recommendations for Periodic Health Examinations.Leawood, KS: American Academy of Family Physicians; 2002.
40. Cooper DS, Halpern R, Wood LC, Levin AA, Ridgway EC. L-Thyroxine therapy in subclinical hypothyroidism.A double-blind placebo-controlled trial. Ann Intern Med. 1984;101.18–24.
41. Nyström E, Caidahl K, Fager G, Wikkelsö C, Lundberg PA, Lindstedt G. A double-blind crossover 12-month study of L-thyroxine treatment of women with \"subclinical\" hypothyroidism.ClinEndocrinol (Oxf) 1988;29; 63-75. [DOI:10.1111/j.1365-2265.1988.tb00250.x]
42. Jaeschke R, Guyatt G, Gerstein H, et al. Does treatment with L-thyroxine influence health status in middle-aged and older adults with subclinical hypothyroidism? J Gen Intern Med. 1996;11.744-749.
43. Meier C, StaubJJ, Roth CB, et al. TSH-controlled L-thyroxine therapy reduces cholesterol levels and clinical symptoms in subclinical hypothyroidism: a double blind, placebo-controlled trial (Basel Thyroid Study) J ClinEndocrinolMetab. 2001;86.4860-4866.
44. Razvi S, Ingoe L, Keeka G, Oates C, McMillan C, Weaver JU. The beneficial effect of L-thyroxine on cardiovascular risk factors, endothelial function, and quality of life in subclinical hypothyroidism: randomized, crossover trial. J ClinEndocrinolMetab. 2007;92.1715-1721.
45. Teixeira PF, Reuters VS, Ferreira MM,
46. Teixeira PF, Reuters VS, Ferreira MM, et al. Lipid profile in different degrees of hypothyroidism and effects of levothyroxine replacement in mild thyroid failure. Transl Res. 2008;151.224-231.
47. Nagasaki T, Inaba M, Yamada S, et al. Decrease of brachial-ankle pulse wave velocity in female subclinical hypothyroid patients during normalization of thyroid function: a double-blind placebo-controlled study. Eur J Endocrinol. 2009;160.409-415.
48. Parle J, Roberts L, Wilson S, et al. A randomized controlled trial of the effect of thyroxine replacement on cognitive function in community-living elderly subjects with subclinical hypothyroidism: the Birmingham Elderly Thyroid Study. J Clin Endocrinol Metab. 2010;95.3623-3632.
49. McCarthy E, Russell A, Kearney PM Management of Patients with Subclinical Hypothyroidism in Primary Care.Ir Med J. 2016;109:346-7.
50. Grossman A, Weiss A, Koren-Morag N, Shimon I, Beloosesky Y, Meyerovitch J Subclinical Thyroid Disease and Mortality in the Elderly: A Retrospective Cohort Study. Am J Med. 2016;129:423-30. [DOI:10.1016/j.amjmed.2015.11.027]
51. Hennessey JV, Espaillat R. Diagnosis and Management ofSubclinical Hypothyroidism in Elderly Adults: A Review of the Literature.J Am Geriatr Soc. 2015;63:1663-73. [DOI:10.1111/jgs.13532]
52. Jones CM, BoelaertK The Endocrinology of Ageing: A Mini-Review. Gerontology. 2015;61:291-300. [DOI:10.1159/000367692]
53. Tolone S, Bondanese M, Ruggiero R, Gili S, Pirozzi R, Parisi S, Buonomo N, Napolitano V, Docimo L, Docimo G. Outcomes of sutureless total thyroidectomy in elderly.Int J Surg. 2016;Sep;33Suppl 1:S16-9. [DOI:10.1016/j.ijsu.2016.05.056]

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