Volume 4, Issue 3 ( Journal of Clinical and Basic Research (JCBR) 2020)
jcbr 2020, 4(3): 3-9 |
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Mehri M, Hosseinzadeh Kakroudi S, Askari F S, Mohebbi A, Tabarraei A. Prevalence of Human Papillomavirus Genotypes in Patients with Genital Warts in Gorgan, Iran. jcbr 2020; 4 (3) :3-9
URL: http://jcbr.goums.ac.ir/article-1-259-en.html
URL: http://jcbr.goums.ac.ir/article-1-259-en.html
Majid Mehri1 
, Saied Hosseinzadeh Kakroudi1 , Fatemeh Sana Askari2 , Alireza Mohebbi2 , Alijan Tabarraei * 
3
, Saied Hosseinzadeh Kakroudi1 , Fatemeh Sana Askari2 , Alireza Mohebbi2 , Alijan Tabarraei * 3
1- Department of Internal Medicine, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
2- Department of Microbiology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
3- Department of Microbiology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran ,Tabarraei@goums.ac.ir
2- Department of Microbiology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
3- Department of Microbiology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran ,
Abstract: (3269 Views)
Background and objectives: Low-risk and high-risk human papillomavirus (HPV) genotypes are the main cause of anogenital warts. The present study aimed to determine prevalence of HPV genotypes in patients with anogenital warts in Gorgan, northeast of Iran.
Methods: In this cross-sectional study, 40 biopsy samples were taken from patients with anogenital warts in Gorgan, Iran. After DNA extraction, multiplex polymerase chain reaction was carried out for detecting HPV genotypes 54, 18, 16 and 6. Demographic characteristics of subjects including gender, age, education level, marital status, smoking and method of contraception were also collected. Data were analyzed in SPSS 16 software at statistical significance of 0.05.
Results: The mean age of male and female patients was 31.81±6.9 and 27.95±6.92 years, respectively. The frequency of HPV-6, HPV-16 and HPV-54 was 77%, 15% and 7.5%, respectively. In addition, HPV-18 was not detected in the collected specimens. Co-infection of HPV-54 with HPV-6 and HPV-16 was also observed in some cases. No significant association was found between HPV infection and age, gender, smocking, contraceptive method and education level.
Conclusions: Similar to previous studies in Iran and other countries, HPV type 6 is the predominant cause of genital warts in Gorgan, Iran. Further studies with a larger study population are needed to explore the role of other contributors to HPV-induced genital warts.
Methods: In this cross-sectional study, 40 biopsy samples were taken from patients with anogenital warts in Gorgan, Iran. After DNA extraction, multiplex polymerase chain reaction was carried out for detecting HPV genotypes 54, 18, 16 and 6. Demographic characteristics of subjects including gender, age, education level, marital status, smoking and method of contraception were also collected. Data were analyzed in SPSS 16 software at statistical significance of 0.05.
Results: The mean age of male and female patients was 31.81±6.9 and 27.95±6.92 years, respectively. The frequency of HPV-6, HPV-16 and HPV-54 was 77%, 15% and 7.5%, respectively. In addition, HPV-18 was not detected in the collected specimens. Co-infection of HPV-54 with HPV-6 and HPV-16 was also observed in some cases. No significant association was found between HPV infection and age, gender, smocking, contraceptive method and education level.
Conclusions: Similar to previous studies in Iran and other countries, HPV type 6 is the predominant cause of genital warts in Gorgan, Iran. Further studies with a larger study population are needed to explore the role of other contributors to HPV-induced genital warts.
Article Type: Research |
Subject:
Basic medical sciences
References
1. Unger ER, Ruffin MT, Diaz-Arrastia C.Human papillomaviruses. In: Clinical Gynecology, Second Edition. 2015.p.37181. [View at Publisher] [Google Scholar]
2. Kofoed K, Sand C, Forslund ,MadsenK.Prevalence of human papillomavirus in anal and oral sites among patients with genital warts. Acta Derm Venereol. 014;94(2):207-
https://doi.org/10.2340/00015555-1718 11. [View at Publisher] [DOI] [PubMed] [Google Scholar]
3. Yuanyue L, Baloch Z, Yasmeen N,TaoY,Xiaomei W, Xueshan X. The distribution ofhuman papillomavirus genotypes in cervicalcancer and intraepithelial neoplasia lesionsamong Chinese women in Yunnan Province. JInfec Public Health. 2018;11(1):105-10. [View at Publisher] [PubMed] [Google Scholar]
4. Camara HB, Anyanwu M, Wright E,Kimmitt PT. Human papilloma virus genotype distribution and risk factor analysis amongst reproductive-age women in urban Gambia. J Med Microbiol. 2018;67(11):1645-4.https://doi.org/10.1099/jmm.0.000848
https://doi.org/10.1099/jmm.0.000848 [View at Publisher] [DOI] [PubMed] [Google Scholar]
5. Muñoz N, Bosch FX, De Sanjosé S, Herrero R, Castellsagué X, Shah K V., et al. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med. 2003;348(6):518-27.https://doi.org/10.1056/NEJMoa021641 [DOI] [PubMed] [Google Scholar]
6. Lin CY, Chen HC, Lin RW, You SL, You CM, Chuang LC, et al. Quality assurance of genotyping array for detection and typing of human papillomavirus. J Virol Methods. 2007;140(1-2):1-9.https://doi.org/10.1016/j.jviromet.2006.10.004 [View at Publisher] [DOI] [PubMed] [Google Scholar]
7. Zuna RE, Allen RA, Moore WE, Lu Y, Mattu R, Dunn ST. Distribution of HPV genotypes in 282 women with cervical lesions: Evidence for three categories of intraepithelial lesions based on morphology and HPV type. Mod Pathol. 2007;20(2):167-74.https://doi.org/10.1038/modpathol.3800723 [View at Publisher] [DOI] [PubMed] [Google Scholar]
8. Piana A, Sotgiu G, Castiglia P, Pischedda S,Cocuzza C, Capobianco G, Marras V, DessoleS, Muresu E. Prevalence and type distributionof human papillomavirus infection in womenfrom North Sardinia, Italy. BMC PublicHealth. 2011 Dec 1;11(1):785.https://doi.org/10.1186/1471-2458-11-785 [View at Publisher] [DOI] [PubMed] [Google Scholar]
9. Halfon P, Ravet S, Khiri H, Penaranda G, Lefoll C. Incident HPV 51 infection after prophylactic quadrivalent human papillomavirus (types 6, 11, 16, and 18)L1virus like particle vaccine Gardasil/silgard®.Clin Med Insights Case Reports. 2010;3:69- 71.https://doi.org/10.4137/CCRep.S508 .https://doi.org/10.4137/CCRep.S6177 [View at Publisher] [DOI] [PubMed] [Google Scholar]
10. de Martel C, Plummer M, Vignat J, Franceschi S. Worldwide burden of cancer attributable to HPV by site, country and HPV type. International journal of cancer. 2017 Aug 15;141(4):664-70.https://doi.org/10.1002/ijc.30716 [View at Publisher] [DOI] [PubMed] [Google Scholar]
11. Jalilvand S, Shoja Z, Hamkar R. Human papillomavirus burden in different cancers in Iran: a systematic assessment. Asian Pac J Cancer Prev. 2014 Jan 1;15(17):7029-35.https://doi.org/10.7314/APJCP.2014.15.17.7029 [View at Publisher] [DOI] [PubMed] [Google Scholar]
12. Ebrahimi A, Moradi MR, Rezaei M, Kavoussi H, Madani SH, Mohammadamini K, et al. Comparison of the risk factors and HPV types in males with anogenital warts with and without involvement of the urethral meatus in Western Iran. Acta Dermatovenerologica Alpina, Pannonica Adriat. 2017;26(3):55-8
https://doi.org/10.15570/actaapa.2017.18 [View at Publisher] [DOI] [PubMed] [Google Scholar]
13. Ozaydin-Yavuz G, Bilgili SG, Guducuoglu H, Yavuz IH, Elibuyuk-Aksac S, Karadag AS. Determinants of high-risk human papillomavirus infection in anogenital warts. Postep Dermatologii i Alergol. 2019;36(1):76- 81.https://doi.org/10.5114/ada.2019.82915 [View at Publisher] [DOI] [PubMed] [Google Scholar]
14. Jamshidi M, Shekari M, Nejatizadeh AA, Malekzadeh K, Baghershiroodi M, Davudian P, et al. The impact of human papillomavirus (HPV) types 6, 11 in women with genital warts. Arch Gynecol Obstet. 2012;286(5):1261-7. [View at Publisher] [PubMed] [Google Scholar]
15. Dareng EO, Adebamowo SN, Famooto A, Olawande O, Odutola MK, Olaniyan Y, et al. Prevalence and incidence of genital warts and cervical Human Papillomavirus infections in Nigerian women 11 Medical and Health Sciences 1117 Public Health and Health Services. BMC Infect Dis. 2019;19(1):27.
https://doi.org/10.1186/s12879-018-3582-y [View at Publisher] [DOI] [PubMed] [Google Scholar]
16. Salehi-Vaziri M, Sadeghi F, Hashemi FS, Haeri H, Bokharaei-Salim F, Monavari SH, et al. Distribution of human papillomavirus genotypes in Iranian women according to the severity of the cervical lesion. Iran Red Crescent Med J. 2016;18(4).
https://doi.org/10.5812/ircmj.24458 [View at Publisher] [DOI] [PubMed] [Google Scholar]
17. Salehi-Vaziri M, Sadeghi F, Bokharaei- Salim F, Younesi S, Alinaghi S, Monavari SH, et al. The prevalence and genotype distribution of human papillomavirus in the genital tract of males in Iran. Jundishapur J Microbiol. 2015;8(12). [View at Publisher] [PubMed] [Google Scholar]
18. Jalilian S, Izadi B, Madani SH, Mohajeri P. The prevalence and genotype distribution of human papillomavirus types in the general female population in West of Iran. Jundishapur J Microbiol. 2017;10(3) :e40855.https://doi.org/10.5812/jjm.40855 [View at Publisher] [DOI] [Google Scholar]
19. Sohrabi A, Hajia M. Cervical cancer and genital infections: Assessment of performance and validation in human papillomavirus genotyping assays in Iran, its neighbouring countries and Persian gulf area. Iran J Pathol. 2017;12(1):35-44.
https://doi.org/10.30699/ijp.2017.24229 [View at Publisher] [DOI] [PubMed] [Google Scholar]
20. Sohrabi A, Hajia M, Jamali F, Kharazi F. Is incidence of multiple HPV genotypes rising in genital infections? J Infect Public Health. 2017;10(6):730-3.
https://doi.org/10.1016/j.jiph.2016.10.006 [View at Publisher] [DOI] [PubMed] [Google Scholar]
21. Comparetto C, Borruto F. Human papillomavirus infection: Overview. In: Handbook on Human Papillomavirus: Prevalence, Detection and Management. 2013. [Google Scholar]
22. Lytwyn A, Sellors JW. Sexually transmitted human papillomaviruses: Current concepts and control issues. Can J Hum Sex. 1997;6(2):113-26. [View at Publisher] [Google Scholar]
23. Franco EL. Persistent HPV infection and cervical cancer risk: Is the scientific rationale for changing the screening paradigm enough? Journal of the National Cancer Institute. 2010;102(19):1451-3.
https://doi.org/10.1093/jnci/djq357
https://doi.org/10.4137/CCRep.S6177 [View at Publisher] [DOI] [PubMed] [Google Scholar]
24. Gissmann L, De Villiers E ‐M, Hausen H Zur. Analysis of human genital warts (condylomata acuminata) and other genital tumors for human papillomavirus type 6 DNA. Int J Cancer. 1982;29(2):143-6.https://doi.org/10.1002/ijc.2910290205 [View at Publisher] [DOI] [PubMed] [Google Scholar]
25. Ma L, Lu S, Jiang Y, Li M, Cong X, Cao Y. Distribution of human papillomavirus genotypes (2014-2016) in women with genital warts at a sexually transmitted disease clinic in Beijing, China. Future Virol. 2018;13(2):111. https://doi.org/10.2217/fvl-2017-0097 [View at Publisher] [DOI] [Google Scholar]
26. Favre M, Kremsdorf D, Jablonska S, Obalek S, Pehau‐Arnaudet Gér, Croissant O, et al. Two new human papillomavirus types (HPV54 and 55) characterized from genital
tumours illustrate the plurality of genital HPVs. Int J Cancer. 1990;45(1):40-6. https://doi.org/10.1002/ijc.2910450109 [View at Publisher] [DOI] [PubMed] [Google Scholar]
27. Park SJ, Seo J, Ha SH, Jung GW. Prevalence and determinants of high-risk human papillomavirus infection in male genital warts. Korean J Urol. 2014;55(3):207-12.
https://doi.org/10.4111/kju.2014.55.3.207 [View at Publisher] [DOI] [PubMed] [Google Scholar]
28. Robadi IA, Pharaon M, Ducatman BS.The importance of high-risk human papillomavirus types other than 16 and 18 in cervical neoplasia. Arch Pathol Lab Med.
2018;142(6):693-5. [View at Publisher] [PubMed] [Google Scholar]
29. Boda D, Neagu M, Constantin C,Voinescu RN, Caruntu C, Zurac S, et al. HPV strain distribution in patients with genital warts in a female population sample. Oncol Lett. 2016;12(3):1779-82.https://doi.org/10.3892/ol.2016.4903 [View at Publisher] [DOI] [PubMed] [Google Scholar]
30. Chen X, Li L, Lai Y, Liu Q, Yan J, Tang Y.Characteristics of human papillomaviruses infection in men with genital warts in Shanghai. Oncotarget. 2016;7(33):53903-10.
https://doi.org/10.18632/oncotarget.9708 [View at Publisher] [DOI] [PubMed] [Google Scholar]
31. Luna-Aguirre CM, Reyes-Cortés LM, Torres-Grimaldo AA, Karr-De-León SF, Cerda-Flores RM, Melo-Nava B, et al.Prevalence of human papillomavirus types in North and Central regions of Mexico.Epidemiol Infect. 2018;146(13):1724-30.https://doi.org/10.1017/S0950268818001747 [View at Publisher] [DOI] [PubMed] [Google Scholar]
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