دوره 9، شماره 2 - ( 4-1404 )
جلد 9 شماره 2 صفحات 16-14 |
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Hesam S, Piri F, Moradpour M, Sepehri H. Investigation of the effects of lipopolysaccharide preconditioning on neuropathic pain induced by chronic sciatic nerve constriction injury in rats. jcbr 2025; 9 (2) :14-16
URL: http://jcbr.goums.ac.ir/article-1-513-fa.html
URL: http://jcbr.goums.ac.ir/article-1-513-fa.html
Investigation of the effects of lipopolysaccharide preconditioning on neuropathic pain induced by chronic sciatic nerve constriction injury in rats. Journal of Clinical and Basic Research. 1404; 9 (2) :14-16
چکیده: (523 مشاهده)
Background: Neuropathic pain results from nerve injury and involves pro-inflammatory cytokines that activate pain-sensing neurons, contributing to both the onset and maintenance of pain. This study investigated the effect of lipopolysaccharide (LPS) preconditioning on pain following sciatic nerve constriction in rats.
Methods: Neuropathic pain was induced via the chronic constriction injury (CCI). Rats received 0.1 mg LPS intraperitoneally three days before CCI. They were divided into four groups: control, CCI without LPS, CCI with LPS, and LPS alone. Pain behavior was assessed on days 0, 7, and 14 using acetone and hot plate tests.
Results: LPS alone did not affect pain sensitivity. CCI increased responses to thermal and cold stimuli. However, prior LPS reduced these responses compared to CCI alone.
Conclusion: This study suggests that 0.1 mg LPS can alleviate neuropathic pain by increasing pain threshold after nerve injury.
Methods: Neuropathic pain was induced via the chronic constriction injury (CCI). Rats received 0.1 mg LPS intraperitoneally three days before CCI. They were divided into four groups: control, CCI without LPS, CCI with LPS, and LPS alone. Pain behavior was assessed on days 0, 7, and 14 using acetone and hot plate tests.
Results: LPS alone did not affect pain sensitivity. CCI increased responses to thermal and cold stimuli. However, prior LPS reduced these responses compared to CCI alone.
Conclusion: This study suggests that 0.1 mg LPS can alleviate neuropathic pain by increasing pain threshold after nerve injury.
نوع مقاله: پژوهشي |
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