1- Neuroscience Research Center, Biomedical Research Institute, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran , soqra.hesam@gmail.com
2- Neuroscience Research Center, Biomedical Research Institute, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
2- Neuroscience Research Center, Biomedical Research Institute, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
Abstract: (16 Views)
Background: Neuropathic pain results from nerve injury and involves pro-inflammatory cytokines that activate pain-sensing neurons, contributing to both the onset and maintenance of pain. This study investigated the effect of lipopolysaccharide (LPS) preconditioning on pain following sciatic nerve constriction in rats.
Methods: Neuropathic pain was induced via the chronic constriction injury (CCI). Rats received 0.1 mg LPS intraperitoneally three days before CCI. They were divided into four groups: control, CCI without LPS, CCI with LPS, and LPS alone. Pain behavior was assessed on days 0, 7, and 14 using acetone and hot plate tests.
Results: LPS alone did not affect pain sensitivity. CCI increased responses to thermal and cold stimuli. However, prior LPS reduced these responses compared to CCI alone.
Conclusion: This study suggests that 0.1 mg LPS can alleviate neuropathic pain by increasing pain threshold after nerve injury.
Methods: Neuropathic pain was induced via the chronic constriction injury (CCI). Rats received 0.1 mg LPS intraperitoneally three days before CCI. They were divided into four groups: control, CCI without LPS, CCI with LPS, and LPS alone. Pain behavior was assessed on days 0, 7, and 14 using acetone and hot plate tests.
Results: LPS alone did not affect pain sensitivity. CCI increased responses to thermal and cold stimuli. However, prior LPS reduced these responses compared to CCI alone.
Conclusion: This study suggests that 0.1 mg LPS can alleviate neuropathic pain by increasing pain threshold after nerve injury.
Article Type: Research |
Subject:
Neuroscience
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