[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 1, Issue 3 (Journal of Clinical and Basic Research(JCBR) 2017) ::
jcbr 2017, 1(3): 15-19 Back to browse issues page
Prevalence of Corneal Arcus in Patients Younger Than 50 Years with Non-Alcoholic Fatty Liver Disease in Gorgan, Northeast of Iran
Negar Broomand , Alireza Norouzi , Reza Hosseinpour , Sima Besharat
Abstract:   (202 Views)
Introduction: Corneal arcus caused by lipid deposition around the cornea has been proposed as an early marker for several metabolic disorders and even cardiovascular events. Non-alcoholic fatty liver (NAFLD) is a common health problem diagnosed by elevated liver enzymes and abdominal ultrasound findings. This study was conducted to assess the prevalence of corneal arcus in patients with NAFLD in Gorgan, northeast of Iran.Materials and Methods: This cross-sectional study was performed on 200 NAFLD patients younger than 50 years of age who were referred to hospitals of Gorgan between March 2014 and February 2015. Diagnosis of NAFLD was based on liver function test and abdominal ultrasound examination. Presence of corneal arcus was evaluated by slit-lamp examination. Results: Overall, corneal arcus was found in 91 patients (45.5%). Presence of corneal arcus was significantly correlated with smoking, opium consumption and family history of NAFLD. After controlling the confounding variables )diabetes, hypertension, smoking, hyperlipidemia, age, gender, ethnicity and body mass index(, we found that corneal arcus is significantly associated with history of ischemic heart disease and family history of fatty liver disease.Conclusions: Presence of corneal arcus in patients younger than 50 years with NAFLD is significantly associated with having a history of ischemic heart disease and family history of fatty liver disease. 
Keywords: Corneal arcus, Non-alcoholic fatty liver disease (NAFLD), Liver enzymes
Full-Text [PDF 370 kb]   (76 Downloads)    
Type of Study: Research | Subject: Genaral
Received: 2017/06/19 | Accepted: 2017/12/6 | Published: 2017/12/11
References
1. Zech LA, Hoeg JM. Correlating corneal arcus with atherosclerosis in familial hypercholesterolemia. Lipids Health Dis. 2008;7(1):7. [DOI:10.1186/1476-511X-7-7]
2. Meyer D, Liebenberg P, Maritz F. Serum lipid parameters and the prevalence of corneal arcus in a dyslipidaemic patient population. Cardiovasc J S Afr. 2004;15(4):166-9.
3. Christoffersen M, Frikke-Schmidt R, Schnohr P, Jensen GB, Nordestgaard BG, Tybjærg-Hansen A. Xanthelasmata, arcus corneae, and ischaemic vascular disease and death in general population: prospective cohort study. BMJ. 2011;343:d5497. [DOI:10.1136/bmj.d5497]
4. Fernandez AB, Keyes MJ, Pencina M, D\'Agostino R, O\'Donnell CJ, Thompson PD. Relation of corneal arcus to cardiovascular disease (from the Framingham Heart Study data set). Am J Cardiol. 2009;103(1):64-6. [DOI:10.1016/j.amjcard.2008.08.030]
5. Raj KM, Reddy PAS, Kumar VC. Significance of corneal arcus. J Pharm Bioallied Sci. 2015;7(Suppl 1):S14-5. [DOI:10.4103/0975-7406.155765]
6. Hashimoto E, Taniai M, Tokushige K. Characteristics and diagnosis of NAFLD/NASH. J Gastroenterol Hepatol. 2013;28 (Suppl 4):64-70. [DOI:10.1111/jgh.12271]
7. Lonardo A, Nascimbeni F, Maurantonio M, Marrazzo A, Rinaldi L, Adinolfi LE. Nonalcoholic fatty liver disease: Evolving paradigms. World J Gastroenterol. 2017; 23(36):6571-6592. [DOI:10.3748/wjg.v23.i36.6571]
8. Hashemi H, Khabazkhoob M, Emamian MH, Shariati M, Fotouhi A. A Population-based Study of Corneal Arcus and its Risk Factors in Iran. Ophthalmic Epidemiol. 2014;21(5):339-44. [DOI:10.3109/09286586.2014.949782]
9. Moosavi M, Sareshtedar A, Zarei-Ghanavati S, Zarei-Ghanavati M, Ramezanfar N. Risk Factors for Senile Corneal Arcus in Patients with Acute Myocardial Infarction. J Ophthalmic Vis Res. 2010;5(4):228.
10. Ang M, Wong W, Park J, Wu R, Lavanya R, Zheng Y, et al. Corneal arcus is a sign of cardiovascular disease, even in low-risk persons. Am J Ophthalmol. 2011;152(5):864-71. [DOI:10.1016/j.ajo.2011.04.014]
11. Lertchavanakul A, Laksanaphuk P, Tomtitchong T. Corneal arcus associated with dyslipidemia. J Med Assoc Thai. 2002;85:S231-5.
Add your comments about this article
Your username or Email:

Write the security code in the box >



XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Broomand N, Norouzi A, Hosseinpour R, Besharat S. Prevalence of Corneal Arcus in Patients Younger Than 50 Years with Non-Alcoholic Fatty Liver Disease in Gorgan, Northeast of Iran. jcbr. 2017; 1 (3) :15-19
URL: http://jcbr.goums.ac.ir/article-1-76-en.html


Volume 1, Issue 3 (Journal of Clinical and Basic Research(JCBR) 2017) Back to browse issues page
Journal of Clinical and Basic Research Journal of Clinical and Basic Research
Persian site map - English site map - Created in 0.05 seconds with 820 queries by yektaweb 3604