دوره 8، شماره 2 - ( 4-1403 )
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Abdulraheem Handhal A, Gholipur M, Mohammad zadeh F, Ghorbani S, Khajeniazi S. Evaluation of the relationship between Hs-CRP and lipid profile in patients with hypothyroidism. jcbr 2024; 8 (2) :1-4
URL: http://jcbr.goums.ac.ir/article-1-444-fa.html
URL: http://jcbr.goums.ac.ir/article-1-444-fa.html
Evaluation of the relationship between Hs-CRP and lipid profile in patients with hypothyroidism. Journal of Clinical and Basic Research. 1403; 8 (2) :1-4
چکیده: (1324 مشاهده)
Background: Hypothyroidism is a significant contributor to complications in various metabolic and cardiovascular diseases. Thyroid hormones, including lipids, play a crucial role in macromolecule metabolism. C-reactive protein (CRP) is a key marker for cardiovascular diseases and hypothyroidism independently. This study aimed to evaluate serum high-sensitivity CRP (Hs-CRP) levels, lipid profiles, and their relationship with thyroid hormones in patients with hypothyroidism compared to a control group.
Methods: This case-control study included 90 participants (45 hypothyroid patients and 45 healthy controls). Blood samples were collected, centrifuged to separate serum, and analyzed using commercial kits. ELISA measured T3, T4, TSH, and Hs-CRP, while TG, HDL, LDL, VLDL, and total cholesterol were measured by spectroscopy.
Results: The findings revealed higher Hs-CRP levels in hypothyroid patients compared to controls, although not statistically significant (P-value = 0.09). Hs-CRP positively correlated with TSH, T3, and TG but negatively correlated with T4, total cholesterol, VLDL, and HDL in hypothyroid subjects. These correlations were only significant between Hs-CRP and TG and Hs-CRP and LDL (P-value < 0.05).
Conclusion: The positive correlation between Hs-CRP and TSH in hypothyroidism highlights a potential link between hypothyroidism and cardiovascular disease.
Methods: This case-control study included 90 participants (45 hypothyroid patients and 45 healthy controls). Blood samples were collected, centrifuged to separate serum, and analyzed using commercial kits. ELISA measured T3, T4, TSH, and Hs-CRP, while TG, HDL, LDL, VLDL, and total cholesterol were measured by spectroscopy.
Results: The findings revealed higher Hs-CRP levels in hypothyroid patients compared to controls, although not statistically significant (P-value = 0.09). Hs-CRP positively correlated with TSH, T3, and TG but negatively correlated with T4, total cholesterol, VLDL, and HDL in hypothyroid subjects. These correlations were only significant between Hs-CRP and TG and Hs-CRP and LDL (P-value < 0.05).
Conclusion: The positive correlation between Hs-CRP and TSH in hypothyroidism highlights a potential link between hypothyroidism and cardiovascular disease.
نوع مقاله: پژوهشي |
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