Volume 6, Issue 4 (Journal of Clinical and Basic Research (JCBR) 2022)
jcbr 2022, 6(4): 6-8 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Mohanty N R, Panda B. Prevalence of Impaired Fasting Glucose and Impaired Glucose Tolerance in Non-Diabetic Patients with Coronary Artery Disease. jcbr 2022; 6 (4) :6-8
URL: http://jcbr.goums.ac.ir/article-1-389-en.html
URL: http://jcbr.goums.ac.ir/article-1-389-en.html
1- Asst.prof. Department of General Medicine,KIMS Hospital,Bhubaneswar
2- Asst.prof. Department of General Medicine,SCB Medical college,Cuttack , dr.bhagyashree.panda@gmail.com
2- Asst.prof. Department of General Medicine,SCB Medical college,Cuttack , dr.bhagyashree.panda@gmail.com
Abstract: (1054 Views)
Background: Coronary artery disease (CAD) is one of the most common morbidities associated with diabetes mellitus. Impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) are precursors to diabetes and major risk factors for atherosclerosis. The study aimed to evaluate the prevalence of IFG and IGT in nondiabetic patients with CAD.
Methods: The study was performed on 100 non-diabetic patients with CAD and 50 healthy age- and sex-matched controls. Data were collected via detailed medical history taking, clinical examination, routine blood chemistry tests, fasting blood sugar test, 2-hour post-prandial blood sugar test, lipid profile, electrocardiogram, 2D-echocardiogram, and carotid Doppler.
Results: Dyslipidemia was more prevalent among the patients. The mean carotid intima–media thickness was higher in the patients. Overall, IFG was found in 9 (15%) cases and IGT was found in 13 (22%) cases. The co-existence of IFG and IGT was detected in 3 (5%) cases. Abnormal glucose regulation was found in 42% of patients.
Conclusion: The findings indicate the need for early screening and management of prediabetes for the prevention of further progression to diabetes.
Methods: The study was performed on 100 non-diabetic patients with CAD and 50 healthy age- and sex-matched controls. Data were collected via detailed medical history taking, clinical examination, routine blood chemistry tests, fasting blood sugar test, 2-hour post-prandial blood sugar test, lipid profile, electrocardiogram, 2D-echocardiogram, and carotid Doppler.
Results: Dyslipidemia was more prevalent among the patients. The mean carotid intima–media thickness was higher in the patients. Overall, IFG was found in 9 (15%) cases and IGT was found in 13 (22%) cases. The co-existence of IFG and IGT was detected in 3 (5%) cases. Abnormal glucose regulation was found in 42% of patients.
Conclusion: The findings indicate the need for early screening and management of prediabetes for the prevention of further progression to diabetes.
Keywords: Prediabetic State, coronary artery disease, Impaired glucose Regulation, Glucose Tolerance test, Intimal media thickness
References
1. Morrow DA, Gersh BJ. Chronic coronary artery disease. In: Libby P, Bonow RO, Mann DL, Tomaselli GF, Bhatt DL, Solomon SD, et al editors. Braunwald’s heart disease: a textbook of cardiovascular medicine. Philadelphia:Elsevier;2008.ch 54. 1353-1417. [View at Publisher] [Google Scholar]
2. Antman EM, Loscalzo J. Harrison's principles of internal medicine; Ischemic Heart Disease: chapter 267. 20th ed. vol 2:1850-1866. [View at Publisher] [Google Scholar]
3. Pradeepa R, Mohan V. Epidemiology of type 2 diabetes in India. Indian J Ophthalmol. 2021; 69(11):2932-2938. [View at Publisher] [DOI] [Google Scholar]
4. Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002; 346:393-403. [View at Publisher] [DOI] [Google Scholar]
5. Intensive blood glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes study (UKPDS) Group. Lancet. 1998, 352(9131):837-853. [View at Publisher] [DOI] [PubMed] [Google Scholar]
6. Bloomgarden ZT. Cardiovascular Disease in diabetes. Diabetes care. 2008; 31(6):1260-1266. [View at Publisher] [DOI] [PubMed] [Google Scholar]
7. Mardikar M, Deo D, Deshpande NV, Khanolkar U, Mathew R, Khan A, et al. Indo Heart Survey on Latent Abnormal Glucose Regulation in Patients with Coronary Artery Disease without Diabetes Across India IHJ. 2008; 60(2):113-118. [View at Publisher] [PubMed] [Google Scholar]
8. Faeh D, William J, Yerly P, Paccaud F, Bovet P. Diabetes and pre-diabetes are associated with cardiovascular risk factors and carotid/femoral intima-media thickness independently of markers of insulin resistance and adiposity. Cardiovascular Diabetology. 2007; 6:32. [View at Publisher] [DOI] [Google Scholar]
9. Hu DY, Pan CY, Yu JM. The relationship between coronary artery disease and abnormal glucose regulation in China: the China Heart Survey. China Heart Survey Group. Eur Heart J. 2006; 27(21):2573-9. [View at Publisher] [DOI] [Google Scholar]
10. Wagenknecht LE, D'Agostino R Jr, Savage PJ, O'Leary DH, Saad MF, Haffner SM. Duration of diabetes and carotid wall thickness. The Insulin Resistance Atherosclerosis Study (IRAS). Stroke. 1997; 28(5): 999-1005. [View at Publisher] [DOI] [Google Scholar]
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0).