Volume 5, Issue 4 ( Journal of Clinical and Basic Research (JCBR) 2021)                   jcbr 2021, 5(4): 1-8 | Back to browse issues page

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GAIKWAD K, SELKAR S. Evaluation of Pre-Analytical Errors in Clinical Biochemistry Laboratory of a Tertiary Care Center in India. jcbr 2021; 5 (4) :1-8
URL: http://jcbr.goums.ac.ir/article-1-334-en.html
1- Department of Biochemistry, Shyam Shah Medical College, REWA, Madhya Pradesh, India , drkapila27@gmail.com
2- Department of Musculoskeletal Sciences, Datta Meghe College of Physiotherapy, Wanadongri, Nagpur, Maharashtra, India
Abstract:   (1421 Views)
Background and objectives: Laboratory medicine is equally challenged by economic and new technological pressures. Clinical laboratories have undergone major change due to advancement of technology, which has improved the decision making of clinicians but introduced the risk of errors. This study aimed to evaluate the errors that occurred in the pre-analytical phase of laboratory testing.
Methods: This was a prospective observational study that was done in the Clinical Biochemistry Laboratory of a tertiary care center from June 2016 to May 2017. The path of the sample was analyzed from sample collection to transport. Frequency of deficiencies in the request forms and different types of pre-analytical errors were recorded.
Results: During the study period, the frequency of pre-analytical errors was about 3.1%. Sample hemolysis was the predominant error in sample collected from both indoor and outdoor patients.
Conclusion: Proper management of pre-analytical errors requires continuous evaluation of source of errors, taking corrective measures, and significant interdepartmental cooperation.
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Article Type: Research | Subject: Biochemistry
Received: 2021/09/25 | Accepted: 2021/10/27 | Published: 2021/12/19

1. Cornes MP, Atherton J, Pourmahram G, Borthwick H, Kyle B, West J, et al. Monitoring and reporting of preanalytical errors in laboratory medicine: the UK situation. Ann Clin Biochem [Internet]. SAGE Publications; 2016 Mar;53(2):279-84 [View at Publisher] [DOI] [PMID] [Google Scholar]
2. Plebani M. Errors in clinical laboratories or errors in laboratory medicine? Clin Chem Lab Med .2006 Jun 1;44(6):750-9 [View at Publisher] [DOI] [PMID] [Google Scholar]
3. Atay A, Demir L, Cuhadar S, Saglam G, Unal H, Aksun S, Arslan B, Ozkan A, Sutcu R. Clinical biochemistry laboratory rejection rates due to various types of preanalytical errors. Biochemia medica. 2014 Oct 15;24(3):376-82. [View at Publisher] [DOI] [PMID] [PMCID] [Google Scholar]
4. Hawkins R. Managing the pre-and post-analytical phases of the total testing process. Annals of laboratory medicine. 2012 Jan 1;32(1):5-16. [View at Publisher] [DOI] [PMID] [PMCID] [Google Scholar]
5. Butterly JR, Horowitz RE. Controversies in laboratory medicine: a series from the institute for quality in laboratory medicine. Medscape General Medicine. 2006;8(1):47. [PubMed] [Google Scholar]
6. Bonini P, Plebani M, Ceriotti F, Rubboli F. Errors in laboratory medicine. Clinical chemistry. 2002 May 1;48(5):691-8. [DOI] [PMID] [Google Scholar]
7. Sharma P. Preanalytical variables and laboratory performance. Indian Journal of Clinical Biochemistry. 2009 Apr;24(2):109. [View at Publisher] [DOI] [PMID] [PMCID] [Google Scholar]
8. Lippi G, Guidi GC. Risk management in the preanalytical phase of laboratory testing. Clin Chem Lab Med, 2007;45:720-7 [DOI] [PMID] [Google Scholar]
9. Lippi G, Chance JJ, Church S, Dazzi P, Fontana R, Giavarina D, Grankvist K, Huisman W, Kouri T, Palicka V, Plebani M. Preanalytical quality improvement: from dream to reality. Clinical chemistry and laboratory medicine. 2011 Jul 1;49(7):1113-26. [View at Publisher] [DOI:10.1515/CCLM.2011.600] [PMID] [Google Scholar]
10. Cornes MP, Atherton J, Pourmahram G, Borthwick H, Kyle B, West J. Monitoring and reporting of preanalytical errors in laboratory medicine: The UK situation. Ann Clin Biochem, 2016; 53(2): 279-284. [View at Publisher] [DOI] [PMID] [Google Scholar]
11. Plebani M. Quality indicators to detect pre-analytical errors in laboratory testing. The Clinical Biochemist Reviews. 2012 Aug;33(3):85 [View at Publisher] [PubMed] [Google Scholar]
12. Medical laboratories - Reduction of error through risk management and continual improvement (ISO/TS 22367:2008, including Cor 1:2009).Published January 2010. Accessed on 21 Nov 2021.
13. Dereen Najat; Prevalence of Pre-Analytical Errors in Clinical Chemistry Diagnostic Labs in Sulaimani City of Iraqi Kurdistan. PLoS One. 2017; 12(1). [View at Publisher] [DOI] [PMID] [PMCID] [Google Scholar]
14. Olayemi E, Asiamah-Broni R. Evaluation of request forms submitted to the haematology laboratory in a Ghanaian tertiary hospital. Pan African Medical Journal. 2011;8(1). [View at Publisher] [DOI] [PMID] [PMCID] [Google Scholar]
15. Ezzelle J, Rodriguez-Chavez IR, Darden JM, Stirewalt M, Kunwar N, Hitchcock R, Walter T, D'souza MP. Guidelines on good clinical laboratory practice: bridging operations between research and clinical research laboratories. Journal of pharmaceutical and biomedical analysis. 2008 Jan 7;46(1):18-29. [View at Publisher] [DOI] [PMID] [PMCID] [Google Scholar]
16. Nutt L, Zemlin AE, Erasmus RT. Incomplete laboratory request forms: the extent and impact on critical results at a tertiary hospital in South Africa. Annals of clinical biochemistry. 2008 Sep;45(5):463-6. [View at Publisher] [DOI] [PMID] [Google Scholar]
17. Lippi G, Blanckaert N, Bonini P, Green S, Kitchen S, Palicka V, et al. Haemolysis: an overview of the leading cause of unsuitable specimens in clinical laboratories. Clin Chem Lab Med. 2008;46(6):764-772. [View at Publisher] [DOI] [PMID] [Google Scholar]
18. Jeffery J, Sharma A, Ayling RM. Detection of haemolysis and reporting of potassium results in samples from neonates. Annals of clinical biochemistry. 2009 May;46(3):222-5. [View at Publisher] [DOI] [PMID] [Google Scholar]
19. Carraro P, Servidio G, Plebani M. Hemolyzed specimens: a reason for rejection or a clinical challenge?. Clinical chemistry. 2000 Feb 1;46(2):306-8. [DOI] [PMID] [Google Scholar]
20. Cao Y, Branzell I, Vink M. Determination of clinically acceptable cut-offs for hemolysis index: An application of bootstrap method using real-world data. Clinical Biochemistry. 2021 Apr 26. [View at Publisher] [DOI] [PMID] [Google Scholar]
21. wan Azman WN, Omar J, Koon TS, Ismail TS. Hemolyzed specimens: Major challenge for identifying and rejecting specimens in clinical laboratories. Oman medical journal. 2019 Mar;34(2):94. [View at Publisher] [DOI] [PMID] [PMCID] [Google Scholar]
22. Carraro P, Servidio G, Plebani M. Hemolyzed specimens: a reason for rejection or a clinical challenge?. Clinical chemistry. 2000 Feb 1;46(2):306-8. [DOI] [PMID] [Google Scholar]
23. Simundic AM, Nikolac N, Lippi G. Hemolysis detection and management of hemolyzed specimens. Biochemia Medica. 2010 Jun 4;20(2):154-9. [View at Publisher] [DOI] [Google Scholar]
24. Lippi G, Avanzini P, Pavesi F, Bardi M, Ippolito L, Aloe R, Favaloro EJ. Studies on in vitro hemolysis and utility of corrective formulas for reporting results on hemolyzed specimens. Biochemia medica. 2011 Oct 15;21(3):297-305 [View at Publisher] [DOI] [PMID] [Google Scholar]
25. Vermeer HJ, Steen G, Naus AJ, Goevaerts B, Agricola PT, Schoenmakers CH. Correction of patient results for Beckman Coulter LX-20 assays affected by interference due to hemoglobin, bilirubin or lipids: a practical approach. Clin Chem Lab Med. 2007;45(1):114-119. [View at Publisher] [DOI] [PMID] [Google Scholar]
26. Yu Z, Kastenmüller G, He Y, Belcredi P, Möller G, Prehn C, Mendes J, Wahl S, Roemisch-Margl W, Ceglarek U, Polonikov A. Differences between human plasma and serum metabolite profiles. PloS one. 2011 Jul 8;6(7):e21230. [View at Publisher] [DOI] [PMID] [PMCID] [Google Scholar]
27. Mannello F. Serum or Plasma Samples? The "Cinderella" Role of Blood Collection Procedures Preanalytical Methodological Issues Influence the Release and Activity of Circulating Matrix Metalloproteinases and Their Tissue Inhibitors, Hampering Diagnostic Trueness and Leading to Misinterpretation. Arterioscler Thromb Vasc Biol. 2008;28:611-614. [View at Publisher] [DOI] [PMID] [Google Scholar]
28. Teahan O, Gamble S, Holmes E, Waxman J, Nicholson JK, Bevan C, Keun HC. Impact of analytical bias in metabonomic studies of human blood serum and plasma. Analytical chemistry. 2006 Jul 1;78(13):4307-18. [View at Publisher] [DOI] [PMID] [Google Scholar]
29. Al-Ghaithi H, Pathare A, Al-Mamari S, Villacrucis R, Fawaz N, Alkindi S. Impact of Educational Activities in Reducing Pre-Analytical Laboratory Errors: A quality initiative. Sultan Qaboos University Medical Journal. 2017 Aug;17(3):e309. [DOI] [PMID] [PMCID] [Google Scholar]
30. Chhillar N, Khurana S, Agarwal R, Singh NK; Effect of pre-analytical errors on quality of laboratory medicine at a neuropsychiatry institute in north India.Indian J Clin Biochem. 2011 Jan;26(1):46-9 [View at Publisher] [DOI] [PMID] [PMCID] [Google Scholar]

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