Volume 5, Issue 3 ( Journal of Clinical and Basic Research (JCBR) 2021)
jcbr 2021, 5(3): 52-59 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Khosroshahi N, Danaeian M, Tavasoli A, Alehossein S M, Kamrani K, Khabazi Oskuoei A. Evaluation and Comparison of MRI Findings in Children with Global Developmental Delay and Isolated Neurodevelopmental Delay: A Cross-sectional Study. jcbr 2021; 5 (3) :52-59
URL: http://jcbr.goums.ac.ir/article-1-325-en.html
URL: http://jcbr.goums.ac.ir/article-1-325-en.html
Nahideh Khosroshahi1 
, Morteza Danaeian2 , Alireza Tavasoli3 , seyed Mehdi Alehossein4 , Kamyar Kamrani5 , Ayda Khabazi Oskuoei * 6
, Morteza Danaeian2 , Alireza Tavasoli3 , seyed Mehdi Alehossein4 , Kamyar Kamrani5 , Ayda Khabazi Oskuoei * 6
1- MD Child neurologist Department of Pediatics Tehran University of Medical Sciences Bahrami Children Hospital. Tehran, Iran
2- MD Department of Pediatrics. Shahid Sadughi University of Medical Sciences,Yazd,lran
3- MD Division of Pediatric Neurology Children’s Medical Center Tehran University of Medical Science, Tehran, Iran
4- Associate Professor of Radiology Tehran University of Medical Sciences. Tehran, Iran
5- M.D Neonatologist Associate Professor Tehran University of Medical Science. Bahrami Children Hospital NICU department. Tehran, Iran
6- MD Department of Pediatric, Bahrami Children's Hospital, Tehran University of Medical Sciences, Tehran, Iran ,Aydakh334@yahoo.com
2- MD Department of Pediatrics. Shahid Sadughi University of Medical Sciences,Yazd,lran
3- MD Division of Pediatric Neurology Children’s Medical Center Tehran University of Medical Science, Tehran, Iran
4- Associate Professor of Radiology Tehran University of Medical Sciences. Tehran, Iran
5- M.D Neonatologist Associate Professor Tehran University of Medical Science. Bahrami Children Hospital NICU department. Tehran, Iran
6- MD Department of Pediatric, Bahrami Children's Hospital, Tehran University of Medical Sciences, Tehran, Iran ,
Abstract: (2839 Views)
Background and objectives: Neuro-developmental delay (NDD) is a chronic neurologic problem that adversely affects the quality of life of affected individuated. The aim of this study was to compare magnetic resonance imaging (MRI) findings in patients with global developmental delay (GDD) and Isolated NDD and evaluate their efficacy in diagnostic approach to children with NDD.
Methods: A cross-sectional study was designed to enroll all patients with static developmental delay who had been referred to outpatient neurology clinic at Bahrami hospital, Tehran, Iran, between Feb 2012-Feb 2013. Neurologic examination results and the presence of GDD or Isolated NDD in patients were recorded using of a pre-prepared questionnaire, Bayley Scales for Infants and Toddler-4th edition and Denver Developmental Screening Test.
Results: Totally 140 patients with developmental delay were enrolled during the study. 70 patients (50%) had global developmental delay (GDD), and 70 cases (50%) had Isolated NDD. In addition, abnormal associated neurological symptoms were present in 67.9% of patients. Patients whit GDD had significantly probability of abnormal MRI compare to patients with isolated NDD (P<0.001). Furthermore, a great proportion of positive MRI findings was reported from patients with Isolated motor NDD (P=0.007). Microcephaly was the most abnormal neurologic finding in patients with GDD (P=0.04).
Conclusion: A significant proportion of abnormal MRI findings in patients with global developmental delay, confirms the necessity of imaging diagnostic tool, especially brain MRI, in diagnostic approach to patients with GDD. In addition, the benefit of brain MRI in diagnostic approach to children with isolated NDD seems to be low.
Methods: A cross-sectional study was designed to enroll all patients with static developmental delay who had been referred to outpatient neurology clinic at Bahrami hospital, Tehran, Iran, between Feb 2012-Feb 2013. Neurologic examination results and the presence of GDD or Isolated NDD in patients were recorded using of a pre-prepared questionnaire, Bayley Scales for Infants and Toddler-4th edition and Denver Developmental Screening Test.
Results: Totally 140 patients with developmental delay were enrolled during the study. 70 patients (50%) had global developmental delay (GDD), and 70 cases (50%) had Isolated NDD. In addition, abnormal associated neurological symptoms were present in 67.9% of patients. Patients whit GDD had significantly probability of abnormal MRI compare to patients with isolated NDD (P<0.001). Furthermore, a great proportion of positive MRI findings was reported from patients with Isolated motor NDD (P=0.007). Microcephaly was the most abnormal neurologic finding in patients with GDD (P=0.04).
Conclusion: A significant proportion of abnormal MRI findings in patients with global developmental delay, confirms the necessity of imaging diagnostic tool, especially brain MRI, in diagnostic approach to patients with GDD. In addition, the benefit of brain MRI in diagnostic approach to children with isolated NDD seems to be low.
Keywords: Global Developmental Delay, Isolated developmental delay, Magnetic Resonance Imaging, Pediatric.
Article Type: Research |
Subject:
Pediatrics
References
1. Swaiman KF, Ashwal S, Ferriero DM. Pediatric neurology: principles & practice: Elsevier Health Sciences; 2006. [Google Scholar]
2. Jee SH, Szilagyi M, Ovenshire C, Norton A, Conn A-M, Blumkin A, et al. Improved detection of developmental delays among young children in foster care. Pediatrics. 2010;125(2):282-9. [View at Publisher] [DOI] [PMID] [Google Scholar]
3. Disabilities CoCw. Developmental surveillance and screening of infants and young children. Pediatrics. 2001;108(1):192-5. [View at Publisher] [DOI] [PMID] [Google Scholar]
4. Rydz D, Shevell MI, Majnemer A, Oskoui M. Topical review: developmental screening. Journal of child neurology. 2005;20(1):4-21. [View at Publisher] [DOI] [PMID] [Google Scholar]
5. Powell AJ, Myers TD. Developing mental toughness: lessons from paralympians. Frontiers in Psychology. 2017;8:1270. [View at Publisher] [DOI] [PMID] [PMCID] [Google Scholar]
6. Bélanger SA, Caron J. Evaluation of the child with global developmental delay and intellectual disability. Paediatrics & child health. 2018;23(6):403-10. [View at Publisher] [DOI] [PMID] [PMCID] [Google Scholar]
7. Kapoor D, Mukherjee SB. Global Developmental Delay and Intellectual Disability in Indian Children-Where do we Stand? Indian pediatrics. 2018;55(12):1083-5. [View at Publisher] [DOI] [PMID]
8. Shevell M, Ashwal S, Donley D, Flint J, Gingold M, Hirtz D, et al. Practice parameter: evaluation of the child with global developmental delay: report of the Quality Standards Subcommittee of the American Academy of Neurology and The Practice Committee of the Child Neurology Society. Neurology. 2003;60(3):367-80. [View at Publisher] [DOI] [PMID] [Google Scholar]
9. Rajvanshi N, Bhakat R, Saxena S, Rohilla J, Basu S, Nandolia KK, et al. Magnetic Resonance Spectroscopy in Children With Developmental Delay: Time to Look Beyond Conventional Magnetic Resonance Imaging (MRI). Journal of Child Neurology. 2021;36(6):440-6. [View at Publisher] [DOI] [PMID] [Google Scholar]
10. Shevell MI, Majnemer A, Rosenbaum P, Abrahamowicz M. Etiologic yield of single domain developmental delay: a prospective study. The Journal of pediatrics. 2000;137(5):633-7. [View at Publisher] [DOI] [PMID] [Google Scholar]
11. Alamri A, Aljadhai YI, Alrashed A, Alfheed B, Abdelmoaty R, Alenazi S, et al. Identifying Clinical Clues in Children With Global Developmental Delay/Intellectual Disability With Abnormal Brain Magnetic Resonance Imaging (MRI). Journal of Child Neurology. 2021;36(6):432-9. [View at Publisher] [DOI] [PMID] [Google Scholar]
12. Chaudhary K, Kashikar SV, PRADEEP R. MRI ASSESSMENT OF PEDIATRIC DEVELOPMENTAL DELAY. Journal of Evolution of Medical and Dental Sciences. 2021;10(8):479-84. [View at Publisher] [DOI]
13. Momen AA, Jelodar G, Dehdashti H. Brain magnetic resonance imaging findings in developmentally delayed children. International Journal of pediatrics. 2011;2011. [View at Publisher] [DOI] [PMID] [PMCID] [Google Scholar]
14. K. E. MRI findings in children with global developmental delay. Int J Radiol Diagn Imaging. 2020;3(2):07-8. [View at Publisher] [DOI]
15. Ali AS, Syed NP, Murthy G, Nori M, Abkari A, Pooja B, et al. Magnetic resonance imaging (MRI) evaluation of developmental delay in pediatric patients. Journal of clinical and diagnostic research: JCDR. 2015;9(1):TC21. [DOI] [PMID] [PMCID] [Google Scholar]
16. Murias K, Moir A, Myers KA, Liu I, Wei X-C. Systematic review of MRI findings in children with developmental delay or cognitive impairment. Brain and Development. 2017;39(8):644-55. [View at Publisher] [DOI] [PMID] [Google Scholar]
17. Pui MH, Wang Y, Singh N. Magnetization transfer ratio and apparent diffusion coefficient analysis in children with global developmental delay. CMIG Extra: Cases. 2005;29(3):27-32. [View at Publisher] [DOI] [Google Scholar]
18. Trauner D, Wulfeck B, Tallal P, Hesselink J. Neurological and MRI profiles of children with developmental language impairment. Developmental medicine and child neurology. 2000;42(7):470-5.
https://doi.org/10.1017/S0012162200000876 [View at Publisher] [DOI] [PMID] [Google Scholar]
19. Hart A, Widjaja E, Batty R, Rigby A, Griffiths P, Baxter P. DMP019 Magnetic resonance imaging findings in children with developmental delay. European Journal of Paediatric Neurology. 2007 (11):81. [View at Publisher] [DOI] [Google Scholar]
20. Pujol J, López-Sala A, Sebastián-Gallés N, Deus J, Cardoner N, Soriano-Mas C, et al. Delayed myelination in children with developmental delay detected by volumetric MRI. Neuroimage. 2004;22(2):897-903. [View at Publisher] [DOI] [PMID] [Google Scholar]
21. Plante E, Swisher L, Vance R, Rapcsak S. MRI findings in boys with specific language impairment. Brain and language. 1991;41(1):52-66. [View at Publisher] [DOI] [Google Scholar]
22. Candy EJ, Hoon AH, Capute AJ, Bryan RN. MRI in motor delay: important adjunct to classification of cerebral palsy. Pediatric neurology. 1993;9(6):421-9. [View at Publisher] [DOI] [Google Scholar]
23. Habibullah H, Albaradie R, Bashir S. MRI evaluation of global developmental delay: a retrospective study. Dubai Medical Journal. 2020;3(1):1-4. [View at Publisher] [DOI] [Google Scholar]
24. Zeegers M, Pol HH, Durston S, Nederveen H, Schnack H, van Daalen E, et al. No differences in MR-based volumetry between 2-and 7-year-old children with autism spectrum disorder and developmental delay. Brain and Development. 2009;31(10):725-30. [View at Publisher] [DOI] [PMID] [Google Scholar]
25. Wilmott RW. Use of the MRI technique, diffusion tensor imaging, in children with global developmental delay. The Journal of Pediatrics. 2008;152(2):A2. [View at Publisher] [DOI] [Google Scholar]
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0).