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:: Volume 4, Issue 1 (Winter 2020) ::
jcbr 2020, 4(1): 1-5 Back to browse issues page
Effect of Gestational Diabetes on Interventricular Septum Thickness in Newborns in the Golestan Province, Iran
Hassan Esmaeili1 , Bagher Pahlavanzade2 , Mohsen Ebrahimi 3
1- Gorgan Congenital Malformations Research Center, Golestan University of Medical Sciences, Gorgan, Iran
2- Department of Biostatistics, School of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3- Neonatal and Children's Health Research Center, Golestan University of Medical Sciences, Gorgan, Iran , dr.ebrahimi2019@gmail.com
Abstract:   (149 Views)
Background and objectives: Despite advances in prenatal care, there is a high rate of morbidity and mortality in infants of diabetic mothers. Interventricular septal hypertrophy is a well-known congenital heart abnormality in neonates of mothers with gestational diabetes. In this study, we investigate the effect of gestational diabetes mellitus on interventricular septum thickness.
Methods: In this cross-sectional cohort study, 42 neonates from mothers with gestational diabetes mellitus and 42 neonates from non-diabetic mothers were selected from gynecology ward of Sayyad Shirazi Hospital in Gorgan (Iran) between April 2016 and April 2017. Ventricular septum thickness in neonates was measured by M-mode echocardiography. Comparison of septum thickness and frequency of septal hypertrophy between the two groups was performed using t-test, Mann-Whitney test and chi-square test. All statistical analyses were preformed in SPSS 16 at significance level of 0.05.
Results: The mean septum thickness was 4.51±1.58 mm in newborns of non-diabetic mothers and 5.84±1.44 mm in newborns of diabetic mothers (P<0.001). Septal hypertrophy (thickness of ≥6 mm) was significantly more common in newborns of diabetic mothers (P=0.029). In addition, we found no significant difference in septum thickness between newborns of diabetic mothers receiving diet or insulin therapy.
Conclusion: Overall, our findings suggest that there is a significant correlation between gestational diabetes and ventricular septal hypertrophy. In addition, glycemic control with diet or insulin therapy has no significant impact on septum thickness.
Keywords: Gestational diabetes mellitus, ventricular septum, Neonates
Full-Text [PDF 120 kb]   (51 Downloads)    
Article Type: Research | Subject: Pediatrics
Received: 2019/10/20 | Accepted: 2020/03/2 | Published: 2020/02/24
1. Arslan D, Guvenc O, Cimen D, Ulu H, Oran B. Prolonged QT dispersion in the infants of diabetic mothers. Pediatric cardiology. 2014;35(6):1052-6.
2. Chen C, Gui YH, Ren YY, Shi LY. The impacts of maternal gestational diabetes mellitus (GDM) on fetal hearts. Biomedical and Environmental Sciences. 2012;25(1):15-22.
3. Veglio M, Chinaglia A, Cavallo-Perin P. QT interval, cardiovascular risk factors and risk of death in diabetes. Journal of endocrinological investigation. 2004;27(2):175-81.
4. Arslan D, Oran B, Vatansev H, Cimen D, Guvenc O. The usefulness of plasma asymmetric dimethylarginine (ADMA) levels and tissue doppler echocardiography for heart function in term infants born to mothers with gestational diabetes mellitus. The Journal of Maternal-Fetal & Neonatal Medicine. 2013;26(17):1742-8.
5. Mongiovì M, Fesslova V, Fazio G, Barbaro G, Pipitone S. Diagnosis and prognosis of fetal cardiomyopathies: a review. Current pharmaceutical design. 2010;16(26):2929-34.
6. Vela-Huerta MM, Vargas-Origel A, Olvera-López A. Asymmetrical septal hypertrophy in newborn infants of diabetic mothers. American journal of perinatology. 2000;17(02):089-94.
7. Abu-Sulaiman RM, Subaih B. Congenital heart disease in infants of diabetic mothers: echocardiographic study. Pediatric cardiology. 2004;25(2):137-40.
8. Cooper MJ, Enderlein MA, Tarnoff H, Rogé CL. Asymmetric septal hypertrophy in infants of diabetic mothers: fetal echocardiography and the impact of maternal diabetic control. American journal of diseases of children. 1992;146(2):226-9.
9. El‐Ganzoury MM, El‐Masry SA, El‐Farrash RA, Anwar M, Abd Ellatife RZ. Infants of diabetic mothers: echocardiographic measurements and cord blood IGF‐I and IGFBP‐1. Pediatric diabetes. 2012;13(2):189-96.
10. Åman J, Hansson U, Östlund I, Wall K, Persson B. Increased fat mass and cardiac septal hypertrophy in newborn infants of mothers with well-controlled diabetes during pregnancy. Neonatology. 2011;100(2):147-54.
11. Sheehan PQ, Rowland TW, Shah BL, McGravey VJ, Reiter EO. Maternal diabetic control and hypertrophic cardiomyopathy in infants of diabetic mothers. Clinical Pediatrics. 1986;25(5):266-71.
12. Ren Y, Zhou Q, Yan Y, Chu C, Gui Y, Li X. Characterization of fetal cardiac structure and function detected by echocardiography in women with normal pregnancy and gestational diabetes mellitus. Prenatal diagnosis. 2011;31(5):459-65.
13. Alsweiler JM, Harding JE, Bloomfield FH. Tight glycemic control with insulin in hyperglycemic preterm babies: a randomized controlled trial. Pediatrics. 2012;129(4):639-47.
14. Weber H, Botti J, Baylen B. Sequential longitudinal evaluation of cardiac growth and ventricular diastolic filling in fetuses of well controlled diabetic mothers. Pediatric cardiology. 1994;15(4):184-9.
15. Gandhi JA, Zhang XY, Maidman JE. Fetal cardiac hypertrophy and cardiac function in diabetic pregnancies. American journal of obstetrics and gynecology. 1995;173(4):1132-6.
16. Weber HS, Copel JA, Reece EA, Green J, Kleinman CS. Cardiac growth in fetuses of diabetic mothers with good metabolic control. The Journal of pediatrics. 1991;118(1):103-7.
17. Oberhoffer R, Högel J, Stoz F, Kohne E, Lang D. Cardiac and extracardiac complications in infants of diabetic mothers and their relation to parameters of carbohydrate metabolism. European journal of pediatrics. 1997;156(4):262-5.
18. Russell NE, Foley M, Kinsley BT, Firth RG, Coffey M, McAuliffe FM. Effect of pregestational diabetes mellitus on fetal cardiac function and structure. American journal of obstetrics and gynecology. 2008;199(3):312. e1-e7.
19. Lin X, Yang P, Reece EA, Yang P. Pregestational type 2 diabetes mellitus induces cardiac hypertrophy in the murine embryo through cardiac remodeling and fibrosis. American journal of obstetrics and gynecology. 2017;217(2):216. e1-e13.
20. Vela-Huerta MM, Amador-Licona N, Villagomez HVO, Ruiz AH, Guizar-Mendoza JM. Asymmetric Septal Hypertrophy in Appropriate for Gestational Age Infants Born to Diabetic Mothers. Indian pediatrics. 2019;56(4):314-6.
21. Babović I, Arandjelović M, Plešinac S, Kontić‐Vučinić O, Radunović N. Maternal glycoregulation in pregnancies complicated by diabetes mellitus in the prediction of fetal echography findings and perinatal outcomes. Journal of Obstetrics and Gynaecology Research. 2018;44(3):432-9.
22. Ghandi Y, Habibi D, Nasri K, Alinejad S, Taherahmad H, Arjmand Shabestari A, et al. Effect of well-controlled gestational diabetes on left ventricular diastolic dysfunction in neonates. The Journal of Maternal-Fetal & Neonatal Medicine. 2019;32(13):2101-6.
23. Semira M, Majid M, Maryam NE, Shamsollah N. Comparison of echocardiographic findings in infants of mothers with gestational diabetes and healthy mothers. Tehran Univ Med J (TUMJ).72(8):9.
24. Gordon EE, Reinking BE, Hu S, Yao J, Kua KL, Younes AK, et al. Maternal hyperglycemia directly and rapidly induces cardiac septal overgrowth in fetal rats. Journal of diabetes research. 2015;2015.
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Esmaeili H, Pahlavanzade B, Ebrahimi M. Effect of Gestational Diabetes on Interventricular Septum Thickness in Newborns in the Golestan Province, Iran. jcbr. 2020; 4 (1) :1-5
URL: http://jcbr.goums.ac.ir/article-1-226-en.html

Volume 4, Issue 1 (Winter 2020) Back to browse issues page
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