Volume 3, Issue 2 ( Journal of Clinical and Basic Research (JCBR) 2019)                   jcbr 2019, 3(2): 8-13 | Back to browse issues page


XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Shokrzadeh M, Hoseinpoor R, Jafari D, Delaram A, Pouyan Sadr A, Deylami M et al . A Ten-Year Study of Drug Poisoning Cases Admitted to the Intensive Care Unit of 5 Azar Hospital in Gorgan, Iran. jcbr 2019; 3 (2) :8-13
URL: http://jcbr.goums.ac.ir/article-1-213-en.html
1- Pharmaceutical Sciences Research Center, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
2- Health Management and Social Development Research Center, Golestan University of Medical Sciences, Gorgan, Iran
3- 5 Azar Hospital, Golestan University of Medical Science, Gorgan, Iran
Abstract:   (3789 Views)
Background and objectives: Drug poisoning is a serious global health problem that sometimes requires hospitalization and intensive care. This study investigates clinical and demographic profile of acute poisoning cases admitted to the intensive care unit (ICU) of 5 Azar hospital in Gorgan, Iran.
Methods: This cross-sectional descriptive study was carried out on 440 acute drug poisoning cases (224 men and 190 women) who had been admitted to the ICU of the hospital from March 2008 to March 2018. Data were collected with a checklist and using the census method. The collected data were analyzed using SPSS (version 16) and the Chi-square test.
Results: Of 440 cases, 54.1% were male and 43.7% were aged 20-29 years. Suicide attempt by self-poisoning was the most important type of poisoning (70.8%). Benzodiazepines (38.9%) and narcotic drugs (18.6%) overdose was the most common cause of acute poisoning. The majority of incidents (72.7%) were caused by a single drug. The average length of stay in the ICU was 4.21 ± 3.45 days. Acute poisoning-related mortality rate was 4.1%, which was primarily due to the use of narcotic drugs.
Conclusion: Benzodiazepines and narcotics are the primary agents involved in acute poisoning requiring critical care. Moreover, methadone-based narcotics are the main cause of drug poisoning-related mortality.
Full-Text [PDF 206 kb]   (1492 Downloads)    
Article Type: Research | Subject: Medicine

References
1. Ibrahim SY, Saad MG, Zaytoun TM. Severe Poisoning cases admitted to the critical care department Alexandria University in 2012: A Retrospective Epidemiological Observational Study. Journal Of Medical Research Institute. 2013; 34(1):1-6. [Google Scholar]
2. Ahuja H, Mathai AS, Pannu A, Arora R. Acute poisonings admitted to a tertiary level intensive care unit in northern India: patient profile and outcomes. Journal of clinical and diagnostic research: JCDR 2015; 9(10):UC01. [DOI] [Google Scholar]
3. Shokrzadeh M, Hajimohammadi A, Hoseinpoor R, Delaram A, Shayeste Y. An epidemiological survey of drug poisoning and a comparison with other poisonings cases admitted to a university hospital in Gorgan, Iran, 2008-2015. International journal of epidemiologic research 2017;4(2):94-103 [In Persian]. [Google Scholar]
4. Shokrzadeh M. Epidemiology of Drug-poisoning Death in Central Cities of Mazandaran, Iran 2011-2016. Journal of Mazandaran University of Medical Sciences. 2017;27(153):140-145[In Persian]. [Google Scholar]
5. Taghaddosinejad F, Sheikhazadi A, Yaghmaei A, Mehrpour O, Schwake L. Epidemiology and treatment of severe poisoning in the intensive care unit: lessons from a one-year prospective observational study. J Clinic Toxicol S. 2012; 2(1):007. [Google Scholar]
6. Orsini J, Din N, Elahi E, Gomez A, Rajayer S, Malik R, Jean E. Clinical and epidemiological characteristics of patients with acute drug intoxication admitted to ICU. Journal of community hospital internal medicine perspectives. 2017;7(4):202-207. [DOI] [Google Scholar]
7. Okumura Y, Shimizu S, Ishikawa KB, Matsuda S, Fushimi K, Ito H. Comparison of emergency hospital admissions for drug poisoning and major diseases: a retrospective observational study using a nationwide administrative discharge database. BMJ open. 2012;2(6):e001857. [DOI] [Google Scholar]
8. Mehdizadeh G, Manouchehri AA, Zarghami A, Moghadamnia AA. Prevalence and causes of poisoning in patients admitted to Shahid Beheshti hospital of Babol in 2011-2012. Journal of Babol University of Medical Sciences. 2015;17(7):22-28 [In Persian]. [Google Scholar]
9. Liakoni E, Dolder PC, Rentsch K, Liechti ME. Acute health problems due to recreational drug use in patients presenting to an urban emergency department in Switzerland. Swiss medical weekly 2015;145(w14166):w14166. [DOI] [Google Scholar]
10. Dines AM, Wood DM, Yates C, Heyerdahl F, Hovda KE, Giraudon I, Sedefov R, Dargan PI, Euro-DEN Research Group. Acute recreational drug and new psychoactive substance toxicity in Europe: 12 months data collection from the European Drug Emergencies Network (Euro-DEN). Clinical Toxicology. 2015;53(9):893-900. [DOI] [Google Scholar]
11. Cioccari L, Luethi N, Bailey M, Pilcher D, Bellomo R. Characteristics and outcomes of critically ill patients with drug overdose in Australia and New Zealand. Critical Care and Resuscitation 2017;19(1):14-22. [Google Scholar]
12. Jayakrishnan B, Al Asmi A, Ahmed Al Qassabi RN, Mohammed I. Acute drug overdose: clinical profile, etiologic spectrum and determinants of duration of intensive medical treatment. Oman medical journal 2012; 27(6):501-504. [DOI] [Google Scholar]
13. Singh DP, Aacharya RP. Pattern of poisoning cases in Bir Hospital. Journal of institute of medicine 2007;28(1):3-6. [DOI] [Google Scholar]
14. Mehrpour O, Akbari A, Jahani F, Amirabadizadeh A, Allahyari E, Mansouri B, Ng PC. Epidemiological and clinical profiles of acute poisoning in patients admitted to the intensive care unit in eastern Iran (2010 to 2017). BMC emergency medicine 2018 Dec;18(1):30. [DOI] [Google Scholar]
15. Aravind A, Rai M. Pattern of acute poisoning admissions in the medical intensive care unit of a tertiary care hospital. Int J Pharm Sci Drug Res 2014 Jul;6(239):e242. [Google Scholar]
16. Cengiz M, Baysal Z, Ganidagli S, Altindag A. Characteristics of poisoning cases in adult intensive care unit in Sanliurfa, Turkey. Saudi medical journal 2006;27(4):497-502. [Google Scholar]
17. Barnato AE, Hsu HE, Bryce CL, Lave JR, Emlet LL, Angus DC, Arnold RM. Using simulation to isolate physician variation in ICU admission decision making for critically ill elders with end-stage cancer: A pilot feasibility study. Critical care medicine 2008 Dec;36(12):3156. [DOI] [Google Scholar]
18. Torkashvand F, Sheikh Fathollahi M, Shamsi S, Kamali M, Rezaeian M. Evaluating the pattern of acute poisoning in cases referred to the Emergency Department of Ali-ebn Abi Taleb Hospital of Rafsanjan from October 2013 to September 2014. Journal of Rafsanjan University of Medical Sciences 2015 Jun 15;14(4):311-24. [Google Scholar]

Add your comments about this article : Your username or Email:
CAPTCHA

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Journal of Clinical and Basic Research

Designed & Developed by : Yektaweb

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0).