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:: Volume 3, Issue 1 (Journal of Clinical and Basic Research(JCBR) 2019) ::
jcbr 2019, 3(1): 6-10 Back to browse issues page
Evaluation of Fasting Blood Sugar and Lipid Profile in Patients with Type 1 and Type 2 Diabetes and Normoglycemic Individuals in Gorgan, Northeastern
Nasim Arab Sarhadi1, Mohammad-ebrahim Fakhreddin-nejad2, Mohammad-hassan Rajabi1, Soleiman Mokarrari1, Ebrahim Naghipour1, Karkon Hooshmand1, Mohammad Mostakhdem Hashemi *3
1- Shohada Hospital, Gonbad-e-Kavoos, Golestan, Iran
2- 1. Shohada Hospital, Gonbad-e-Kavoos, Golestan, Iran
3- Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran
Abstract:   (337 Views)
Background and objectives: Diabetes mellitus is a major public health issue worldwide.
Poorly managed type 1 and type 2 diabetics are at risk of developing several complications, including cardiovascular disease. Therefore, monitoring lipid profile and glycemic control in such patients are of great importance for reducing the risk of developing diabetic complications. In this study, we measured the level of fasting blood sugar (FBS) and lipid profile components in patients with either type 1 or type 2 diabetes and non-diabetic individuals.
Methods: This cross-sectional case-control study was conducted on 50 type 1 diabetics, 50 type 2 diabetics and 50 normoglycemic individuals (controls). All subjects were matched in terms of age and gender. Serum level of FBS, total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) was measured using commercial kits. Statistical analysis was performed using SPSS software (version 16) at significance level of 0.05.
Results: The levels of FBS, TC, TG, LDL and HDL were higher in both case groups compared to the controls. The value of these variables (except for TC) was significantly higher in patients with type 1 diabetes than in patients with type 2 diabetes.
Conclusion: Our results show that patients with type 2 diabetes have lower levels of HDL compared to T1DM patients, which might increase the risk of developing cardiovascular complications in these patients.
Keywords: Cardiovascular Diseases, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Lipid profile, FBS
Full-Text [PDF 522 kb]   (107 Downloads)    
Article Type: Research | Subject: Medicine
Received: 2019/04/5 | Accepted: 2019/04/15 | Published: 2019/04/29
1. World Health Organization. Definition, diagnosis and classification of diabetes mellitus and its complications: report of a WHO consultation. Part 1, Diagnosis and classification of diabetes mellitus. Geneva: World health organization; 1999.
2. Larsson SC, Wallin A, Håkansson N, Stackelberg O, Bäck M, Wolk A. Type 1 and type 2 diabetes mellitus and incidence of seven cardiovascular diseases. International journal of cardiology. 2018;262:66-70. [DOI:10.1016/j.ijcard.2018.03.099]
3. Saaddine JB, Cadwell B, Gregg EW, Engelgau MM, Vinicor F, Imperatore G, Narayan KV. Improvements in diabetes processes of care and intermediate outcomes: United States, 1988-2002. Annals of internal medicine. 2006 ;144(7):465-74. 4. [DOI:10.7326/0003-4819-144-7-200604040-00005]
4. Verges B. Lipid modification in type 2 diabetes: the role of LDL and HDL. Fundamental & clinical pharmacology. 2009;23(6):681-5. [DOI:10.1111/j.1472-8206.2009.00739.x]
5. Fox CS, Golden SH, Anderson C, Bray GA, Burke LE, De Boer IH, Deedwania P, Eckel RH, Ershow AG, Fradkin J, Inzucchi SE. Update on prevention of cardiovascular disease in adults with type 2 diabetes mellitus in light of recent evidence: a scientific statement from the American Heart Association and the American Diabetes Association. Circulation. 2015 Aug 25;132(8):691-718. [DOI:10.1161/CIR.0000000000000230]
6. Pyörälä K, Laakso M, Uusitupa M. Diabetes and atherosclerosis: an epidemiologic view. Diabetes/metabolism reviews. 1987;3(2):463-524. [DOI:10.1002/dmr.5610030206]
7. Haffner SM, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. New England journal of medicine. 1998 ;339(4):229-34. [DOI:10.1056/NEJM199807233390404]
8. Turner RC, Millns H, Neil HA, Stratton IM, Manley SE, Matthews DR, Holman RR. Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus: United Kingdom Prospective Diabetes Study (UKPDS: 23). Bmj. 1998; 316(7134):823-8. 9. [DOI:10.1136/bmj.316.7134.823]
9. Kim M, Kim M, Yoo HJ, Lee E, Chae JS, Lee SH, Lee JH. A promoter variant of the APOA5 gene increases atherogenic LDL levels and arterial stiffness in hypertriglyceridemic patients. PloS one. 2017 ;12(12):e0186693. [DOI:10.1371/journal.pone.0186693]
10. Hashemi MM, Mansourian AR, Kosari E, Marjani A. Serum Levels of Nitric Oxide, Lipid Profiles, and Fasting Blood Glucose and Their Associations in Subclinical Hypothyroid Women Before and After Treatment by Levothyroxine. Transylvanian Review. 2016; 24 (10): 2689-2696.
11. Taskinen MR. Quantitative and qualitative lipoprotein abnormalities in diabetes mellitus. Diabetes. 1992; 41(Suppl. 2):12-17. [DOI:10.2337/diab.41.2.S12]
12. Mehta R, Reyes-Rodríguez E, Bello-Chavolla OY, Guerrero-Díaz AC, Vargas-Vázquez A, Cruz-Bautista I, Aguilar-Salinas CA. Performance of LDL-C calculated with Martin's formula compared to the Friedewald equation in familial combined hyperlipidemia. Atherosclerosis. 2018; 277:204-10. [DOI:10.1016/j.atherosclerosis.2018.06.868]
13. Suckling KE, Jackson B. Animal models of human lipid metabolism. Progress in lipid research. 1993; 32(1):1-24. [DOI:10.1016/0163-7827(93)90002-E]
14. Suryawanshi NP, Bhutey AK, Nagdeote AN, Jadhav AA, Manoorkar GS. Study of lipid peroxide and lipid profile in diabetes mellitus. Indian Journal of Clinical Biochemistry. 2006; 21(1):126. [DOI:10.1007/BF02913080]
15. Rosenblit PD. Common medications used by patients with type 2 diabetes mellitus: what are their effects on the lipid profile?. Cardiovascular diabetology. 2016; 15(1):95. [DOI:10.1186/s12933-016-0412-7]
16. Marin MT, Dasari PS, Tryggestad JB, Aston CE, Teague AM, Short KR. Oxidized HDL and LDL in adolescents with type 2 diabetes compared to normal weight and obese peers. Journal of Diabetes and its Complications. 2015; 29(5):679-85. [DOI:10.1016/j.jdiacomp.2015.03.015]
17. Drexel H, Aczel S, Marte T, Benzer W, Langer P, Moll W, Saely CH. Is atherosclerosis in diabetes and impaired fasting glucose driven by elevated LDL cholesterol or by decreased HDL cholesterol?. Diabetes care. 2005; 28(1):101-7. [DOI:10.2337/diacare.28.1.101]
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Arab Sarhadi N, Fakhreddin-nejad M, Rajabi M, Mokarrari S, Naghipour E, Hooshmand K et al . Evaluation of Fasting Blood Sugar and Lipid Profile in Patients with Type 1 and Type 2 Diabetes and Normoglycemic Individuals in Gorgan, Northeastern . jcbr. 2019; 3 (1) :6-10
URL: http://jcbr.goums.ac.ir/article-1-193-en.html

Volume 3, Issue 1 (Journal of Clinical and Basic Research(JCBR) 2019) Back to browse issues page
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