Volume 2, Issue 4 (Journal of Clinical and Basic Research(JCBR) 2018)
jcbr 2018, 2(4): 41-47 |
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Chorli F, Ghodsalavi Z, Hajilari M, Dastaviz F, Mehri M, Oladnabi M. Three Women with Non-Segmental Vitiligo in Three Generations of a Family: A Case Report . jcbr 2018; 2 (4) :41-47
URL: http://jcbr.goums.ac.ir/article-1-169-en.html
URL: http://jcbr.goums.ac.ir/article-1-169-en.html
Fatemeh Chorli1 
, Zahra Ghodsalavi1 , Maryam Hajilari1 , Farzad Dastaviz1 , Majid Mehri2 , Morteza Oladnabi * 3
, Zahra Ghodsalavi1 , Maryam Hajilari1 , Farzad Dastaviz1 , Majid Mehri2 , Morteza Oladnabi * 3
1- Student Research Committee, Golestan University of Medical Sciences, Gorgan, Iran
2- Department of Internal Medicine, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
3- Department of Medical Genetics, Gorgan Congenital Malformations Research Center, Golestan University of Medical Sciences, Gorgan, Iran
2- Department of Internal Medicine, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
3- Department of Medical Genetics, Gorgan Congenital Malformations Research Center, Golestan University of Medical Sciences, Gorgan, Iran
Abstract: (3908 Views)
Background: Vitiligo is a common autoimmune skin disorder, which is characterized by incomplete penetrance and genetic heterogeneity. It is classified into two types: segmental and non-segmental, and most cases suffer from non-segmental vitiligo. The disease affects about 2-10 in 1000 people in different population with no sex predilection. Furthermore, the genetics of vitiligo cannot be described by Mendelian pattern of inheritance. We herein report three female relatives (niece, aunt, grandmother) with non-segmental vitiligo in a family.
Case description: The symptoms and severity of the disease varied between the cases. Incomplete penetrance was completely evident in this family. The grandmother had not received any treatment, but the aunt and niece were receiving medication and phototherapy. However, these treatments were not beneficial for them.
Conclusion: Currently there is no effective treatment or screening method for vitiligo. Thus, genetic counseling, risk determination and identification of other genetic contributors could be beneficial.
Case description: The symptoms and severity of the disease varied between the cases. Incomplete penetrance was completely evident in this family. The grandmother had not received any treatment, but the aunt and niece were receiving medication and phototherapy. However, these treatments were not beneficial for them.
Conclusion: Currently there is no effective treatment or screening method for vitiligo. Thus, genetic counseling, risk determination and identification of other genetic contributors could be beneficial.
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