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:: Volume 2, Issue 4 (Journal of Clinical and Basic Research(JCBR) 2018) ::
jcbr 2018, 2(4): 0-0 Back to browse issues page
Three Women with Non-Segmental Vitiligo in Three Generations of a Family: A Case Report
Fatemeh Chorli 1, Zahra Ghodsalavi 1, Maryam Hajilari 1, Farzad Dastaviz 1, Majid Mehri 2, Morteza Oladnabi * 3
1- Student Research Committee, Golestan University of Medical Sciences, Gorgan, Iran
2- Department of Internal Medicine, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
3- Department of Medical Genetics, Gorgan Congenital Malformations Research Center, Golestan University of Medical Sciences, Gorgan, Iran
Abstract:   (45 Views)
Background: Vitiligo is a common autoimmune skin disorder, which is characterized by incomplete penetrance and genetic heterogeneity. It is classified into two types: segmental and non-segmental, and most cases suffer from non-segmental vitiligo. The disease affects about 2-10 in 1000 people in different population with no sex predilection. Furthermore, the genetics of vitiligo cannot be described by Mendelian pattern of inheritance. We herein report three female relatives (niece, aunt, grandmother) with non-segmental vitiligo in a family.
Case description: The symptoms and severity of the disease varied between the cases. Incomplete penetrance was completely evident in this family. The grandmother had not received any treatment, but the aunt and niece were receiving medication and phototherapy. However, these treatments were not beneficial for them.
Conclusion: Currently there is no effective treatment or screening method for vitiligo. Thus, genetic counseling, risk determination and identification of other genetic contributors could be beneficial.
Keywords: Non-segmental vitiligo, Incomplete penetrance, Skin depigmentation
     
Article Type: Research | Subject: Medicine
Received: 2018/12/29 | Accepted: 2018/12/29 | Published: 2018/12/29
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Chorli F, Ghodsalavi Z, Hajilari M, Dastaviz F, Mehri M, Oladnabi M. Three Women with Non-Segmental Vitiligo in Three Generations of a Family: A Case Report . jcbr. 2018; 2 (4)
URL: http://jcbr.goums.ac.ir/article-1-169-en.html


Volume 2, Issue 4 (Journal of Clinical and Basic Research(JCBR) 2018) Back to browse issues page
Journal of Clinical and Basic Research Journal of Clinical and Basic Research
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