[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 2, Issue 2 (Journal of Clinical and Basic Research(JCBR) 2018) ::
jcbr 2018, 2(2): 40-45 Back to browse issues page
Serum Concentrations of Trace Elements in Patients with Ulcerative Colitis
Hamidreza Joshaghani , Taghi Amiriani , Reza Goodarzi , Honeyeh-sadat Mirkarimi , Sima Besharat , Gholamreza Roshandel , Bahar Kolasangiani , Samaneh Sadat Aghili
Abstract:   (19 Views)
Introduction: Nutritional status of patients with inflammatory bowel disease is estimated to be lower than optimal. This study was designed to compare the serum level of some trace elements in patients with ulcerative colitis (UC). Materials and methods: This cross-sectional study was performed in 2015-2016, on 60 recently diagnosed UC patients (30 with active UC and 30 with inactive UC) who were recruited from registry of the Golestan Research Center of Gastroenterology and Hepatology (Gorgan, Iran) through simple random sampling. Thirty healthy individuals were also recruited as controls. Demographic data and disease activity index were recorded through a checklist. Serum levels of copper (Cu), zinc (Zn), selenium (Se) and magnesium (Mg) were measured by atomic absorption spectroscopy. Data were analyzed using SPSS 16 at significance level of 0.05. Results: Mean serum level of Cu in the patients (0.75±0.25 mg/L) was significantly lower than in the controls (1.11±0.3 mg/L) (P=0001). Similarly, mean serum level of Mg in the patients (15.84±4.3 mg/L) was significantly lower than in the controls (19.48±15.7 mg/L) (P=0.001). Mean serum level of Se was slightly higher among the UC patients, while mean serum level of Zn was slightly lower in the UC patients compared with the controls. Conclusions: Our results show that UC patients have significantly lower Cu and Mg levels compared to healthy individuals. However, serum Zn and Se levels do not differ significantly between the UC patients and the control individuals. Further studies are required to confirm the results of this study.
Keywords: Inflammatory bowel diseases, Ulcerative colitis, Trace elements
Full-Text [PDF 162 kb]   (10 Downloads)    
Type of Study: Research | Subject: Medicine
Received: 2018/09/30 | Accepted: 2018/09/30 | Published: 2018/09/30
References
1. Ahmad T, Tamboli CP, Jewell D, Colombel J-F. Clinical relevance of advances in genetics and pharmacogenetics of IBD. Gastroenterology. 2004;126(6):1533-49. [DOI:10.1053/j.gastro.2004.01.061]
2. Park JR, Pfeil SA. Primary Care of the Patient with Inflammatory Bowel Disease. Medical Clinics of North America. 2015;99(5):969-87. [DOI:10.1016/j.mcna.2015.05.009]
3. Shivananda S, Lennard-Jones J, Logan R, Fear N, Price A, Carpenter L, et al. Incidence of inflammatory bowel disease across Europe: is there a difference between north and south? Results of the European Collaborative Study on Inflammatory Bowel Disease (EC-IBD). Gut. 1996;39(5):690-7. [DOI:10.1136/gut.39.5.690]
4. Podolsky DK. Inflammatory bowel disease. N Engl J Med. 1991;325(13):928-37. [DOI:10.1056/NEJM199109263251306]
5. Satsangi J, Grootscholten C, Holt H, Jewell D. Clinical patterns of familial inflammatory bowel disease. Gut. 1996;38(5):738-41. [DOI:10.1136/gut.38.5.738]
6. Bodenheimer HC, Larusso NF, Thayer WR, Charland C, Staples PJ, Ludwig J. Elevated circulating immune complexes in primary sclerosing cholangitis. Hepatology. 1983;3(2):150-4. [DOI:10.1002/hep.1840030203]
7. Song SM, Kim Y, Oh SH, Kim KM. Nutritional status and growth in Korean children with Crohn's disease: a single-center study. Gut & Liver. 2014;8(5). [DOI:10.5009/gnl13183]
8. Faa G, Nurchi VM, Ravarino A, Fanni D, Nemolato S, Gerosa C, et al. Zinc in gastrointestinal and liver disease. Coordination Chemistry Reviews. 2008;252(10):1257-69. [DOI:10.1016/j.ccr.2007.09.024]
9. Tran C, Ball J, Sundar S, Coyle P, Howarth G. The role of zinc and metallothionein in the dextran sulfate sodium-induced colitis mouse model. Digestive diseases and sciences. 2007;52(9):2113-21. [DOI:10.1007/s10620-007-9765-9]
10. Seydkhani Na, Yaghmaei B, Maleki F. Evaluation Of Serum Zinc And Copper Levels In Patients Suffering From Left Anterior Descending Obstruction. Scientific Journal of Ilam Med University. 2009;16(4);55-63. [In Persian]
11. Gröber U, Schmidt J, Kisters K. Magnesium in prevention and therapy. Nutrients. 2015;7(9):8199-226. [DOI:10.3390/nu7095388]
12. Ojuawo A, Keith L. The serum concentrations of zinc, copper and selenium in children with inflammatory bowel disease. Cent Afr J Med. 2002;48(9-10):116-9.
13. Geerling B, Badart-Smook A, Stockbrugger R, Brummer R. Comprehensive nutritional status in recently diagnosed patients with inflammatory bowel disease compared with population controls. Eur J Clin Nutr. 2000;54(6):514-21. [DOI:10.1038/sj.ejcn.1601049]
14. El Muhtaseb MSH, Duncan A, Talwar DK, O'Reilly DSJ, McKee RF, Anderson JH, et al. Assessment of dietary intake and trace element status in patients with ileal pouch-anal anastomosis. Dis Colon Rectum. 2007;50(10):1553-7. [DOI:10.1007/s10350-007-9003-8]
15. Sikora S, Spady D, Prosser C, El-Matary W. Trace elements and vitamins at diagnosis in pediatric-onset inflammatory bowel disease. Clinical pediatrics. 2011,50(6):488-92. [DOI:10.1177/0009922810397041]
16. Dalekos GN, Ringstad J, Seferiadis KI, Tsianos EV. Zinc, copper and immunological markers in the circulation of well nourished patients with ulcerative colitis. Eur J Gastroenterol Hepatol. 1998;10(4):331-8. [DOI:10.1097/00042737-199804000-00010]
17. Sturniolo G, Mestriner C, Lecis P, D'ODORICO A, Venturi C, Irato P, et al. Altered plasma and mucosal concentrations of trace elements and antioxidants in active ulcerative colitis. Scandinavian journal of gastroenterology. 1998;33(6):644-9. [DOI:10.1080/00365529850171936]
18. Whineray E, Inder W, Roche D, Dobbs B, Frizelle F. Comparison of micronutrients in patients having had panproctocolectomy and either ileal pouch anal anastomosis or Brooke ileostomy for chronic ulcerative colitis (UC). Colorectal Dis. 2000;2(6):351-4. [DOI:10.1046/j.1463-1318.2000.00177.x]
19. Aghazadeh R, Zali MR, Bahari A, Amin K, Ghahghaie F, Firouzi F. Inflammatory bowel disease in Iran: a review of 457 cases. Journal of gastroenterology and hepatology. 2005;20(11):1691-5. [DOI:10.1111/j.1440-1746.2005.03905.x]
20. Rahimzadeh H, Sadeghi M, Beirami S , Bay A , Mansurian M , Roshandel Gh. Association of Heavy Metals and Selenium Content in Rice with Incidence of Esophageal Cancer in Golestan Province, Iran. Journal of Clinical and Basic Research. 2017; 1(1):27-32. [DOI:10.18869/acadpub.jcbr.1.1.27]
Add your comments about this article
Your username or Email:

CAPTCHA code


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Joshaghani H, Amiriani T, Goodarzi R, Mirkarimi H, Besharat S, Roshandel G, et al . Serum Concentrations of Trace Elements in Patients with Ulcerative Colitis. jcbr. 2018; 2 (2) :40-45
URL: http://jcbr.goums.ac.ir/article-1-148-en.html


Volume 2, Issue 2 (Journal of Clinical and Basic Research(JCBR) 2018) Back to browse issues page
Journal of Clinical and Basic Research Journal of Clinical and Basic Research
Persian site map - English site map - Created in 0.05 seconds with 31 queries by YEKTAWEB 3764