en Biochemistry مروری Review <span style="font-size:14px;"><span new="" roman="" style="font-family:" times="">Diabetes and diabetic complications have been a global menace for a long time, putting a heavy burden on an individual, the health sector, and governments. Diabetic complications attributed to persistent hyperglycemia create a challenge in managing diabetes, considering the nature of the disease as a group of metabolic disorders. Various phytochemicals target different metabolic pathways and molecules through different mechanisms of action, acting individually or synergistically to achieve therapeutic goals. Phytochemicals such as alkaloids, saponins, glycosides, terpenoids, and flavonoids were reported to exert different anti-diabetic effects, including anti-hyperglycemic, anti-hyperlipidemic, anti-inflammatory, antioxidant, and insulinotropic activities. The present review focused on the recent advances in the therapeutic potentials of phytochemicals in managing diabetes and diabetic complications, emphasizing their in vitro and in vivo studies.</span></span><br> &nbsp; Anti-diabetic, Diabetes mellitus, Medicinal plants, Phytochemicals, Therapeutic roles 13 20 http://jcbr.goums.ac.ir/browse.php?a_code=A-10-389-1&slc_lang=en&sid=1 Muhammad Mubarak Dahiru mubaraq93@gmail.com 10031947532846004370 10031947532846004370 Yes Department of Science Laboratory Technology, School of Science and Technology, Adamawa State Polytechnic, Yola