en ارزیابی و مقایسه یافته های MRI در کودکان با تاخیر رشد جهانی و تاخیر عصبی تکاملی جداگانه: یک مطالعه مقطعی Pediatrics پژوهشي Research <strong>Background and objectives: </strong>Neuro-developmental delay (NDD) is a chronic neurologic problem that adversely affects the quality of life of affected individuated. The aim of this study was to compare magnetic resonance imaging (MRI) findings in patients with global developmental delay (GDD) and Isolated NDD and evaluate their efficacy in diagnostic approach to children with NDD.<br> <strong>Methods: </strong>A cross-sectional study was designed to enroll all patients with static developmental delay who had been referred to outpatient neurology clinic at Bahrami hospital, Tehran, Iran, between Feb 2012-Feb 2013. Neurologic examination results and the presence of GDD or Isolated NDD in patients were recorded using of a pre-prepared questionnaire, Bayley Scales for Infants and Toddler-4^th edition and Denver Developmental Screening Test.<br> <strong>Results: </strong>Totally 140 patients with developmental delay were enrolled during the study. 70 patients (50%) had global developmental delay (GDD), and 70 cases (50%) had Isolated NDD. In addition, abnormal associated neurological symptoms were present in 67.9% of patients. Patients whit GDD had significantly probability of abnormal MRI compare to patients with isolated NDD (P<0.001). Furthermore, a great proportion of positive MRI findings was reported from patients with Isolated motor NDD (P=0.007). Microcephaly was the most abnormal neurologic finding in patients with GDD (P=0.04).<br> <strong>Conclusion: </strong>A significant proportion of abnormal MRI findings in patients with global developmental delay, confirms the necessity of imaging diagnostic tool, especially brain MRI, in diagnostic approach to patients with GDD. In addition, the benefit of brain MRI in diagnostic approach to children with isolated NDD seems to be low. <strong>Background and objectives: </strong>Neuro-developmental delay (NDD) is a chronic neurologic problem that adversely affects the quality of life of affected individuated. The aim of this study was to compare magnetic resonance imaging (MRI) findings in patients with global developmental delay (GDD) and Isolated NDD and evaluate their efficacy in diagnostic approach to children with NDD.<br> <strong>Methods: </strong>A cross-sectional study was designed to enroll all patients with static developmental delay who had been referred to outpatient neurology clinic at Bahrami hospital, Tehran, Iran, between Feb 2012-Feb 2013. Neurologic examination results and the presence of GDD or Isolated NDD in patients were recorded using of a pre-prepared questionnaire, Bayley Scales for Infants and Toddler-4^th edition and Denver Developmental Screening Test.<br> <strong>Results: </strong>Totally 140 patients with developmental delay were enrolled during the study. 70 patients (50%) had global developmental delay (GDD), and 70 cases (50%) had Isolated NDD. In addition, abnormal associated neurological symptoms were present in 67.9% of patients. Patients whit GDD had significantly probability of abnormal MRI compare to patients with isolated NDD (P<0.001). Furthermore, a great proportion of positive MRI findings was reported from patients with Isolated motor NDD (P=0.007). Microcephaly was the most abnormal neurologic finding in patients with GDD (P=0.04).<br> <strong>Conclusion: </strong>A significant proportion of abnormal MRI findings in patients with global developmental delay, confirms the necessity of imaging diagnostic tool, especially brain MRI, in diagnostic approach to patients with GDD. In addition, the benefit of brain MRI in diagnostic approach to children with isolated NDD seems to be low. تاخیر توسعه جهانی ؛ تأخیر جداگانه در رشد ؛ تصویربرداری رزونانس مغناطیسی , کودکان. Global Developmental Delay, Isolated developmental delay, Magnetic Resonance Imaging, Pediatric. 52 59 http://jcbr.goums.ac.ir/browse.php?a_code=A-10-234-1&slc_lang=en&sid=1 Nahideh Khosroshahi na.khosroshahi@gmail.com 10031947532846005244 10031947532846005244 No MD Child neurologist Department of Pediatics Tehran University of Medical Sciences Bahrami Children Hospital. Tehran, Iran Morteza Danaeian drdanaeian@gmail.com 10031947532846005245 0000000255529644 No MD Department of Pediatrics. Shahid Sadughi University of Medical Sciences,Yazd,lran Alireza Tavasoli A_tavasoli@sina.tums.ac.ir 10031947532846005246 0000000304405809 No MD Division of Pediatric Neurology Children’s Medical Center Tehran University of Medical Science, Tehran, Iran seyed Mehdi Alehossein mehdialehossein@yahoo.com 10031947532846005247 10031947532846005247 No Associate Professor of Radiology Tehran University of Medical Sciences. Tehran, Iran Kamyar Kamrani kamyarkamrani48@gmail.com 10031947532846005248 10031947532846005248 No M.D Neonatologist Associate Professor Tehran University of Medical Science. Bahrami Children Hospital NICU department. Tehran, Iran Ayda Khabazi Oskuoei Aydakh334@yahoo.com 10031947532846005249 10031947532846005249 Yes MD Department of Pediatric, Bahrami Children's Hospital, Tehran University of Medical Sciences, Tehran, Iran