fa Medicine پژوهشي Research <strong>Background: </strong>Proteus syndrome is a rare genetic disorder characterized by overgrowth of bones, skin, and other tissues, with vascular malformations, epidermal moles, and subcutaneous masses. We herein present a case of Proteus syndrome with extensive hemangiomas.<br> <strong>Case description:</strong> An 11-year-old girl with Proteus syndrome was presented with extensive hemangioma, asymmetrical growth in lower limbs, skin and bone lesions, and facial hemihypertrophy.<br> <strong>Conclusions:</strong> Given the severe complications of this syndrome and the risk of early death in the patients, early diagnosis is essential for reducing the risk of morbidity and mortality. These patients should be followed up for progressive skeletal deformities, hemangiomas, and malignant or benign tumors. In our case, risk of thrombosis and pulmonary embolism limited surgical intervention. <div></div> Proteus Syndrome, Hemangioma, Facial hemihypertrophy 19 24 http://jcbr.goums.ac.ir/browse.php?a_code=A-10-117-1&slc_lang=fa&sid=1 Jabbar Parhiz جبار پرهیز 10031947532846001720 10031947532846001720 Yes Neonatal and Children's Health Research Center, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran Atefeh Kami عاطفه کرمی 10031947532846001721 10031947532846001721 No Taleghani Hospital, Golestan University of Medical Sciences, Gorgan, Iran Narges Lashkarbolouk نرگس لشکربلوک 10031947532846001722 10031947532846001722 No Taleghani Hospital, Golestan University of Medical Sciences, Gorgan, Iran Hamid Soltani Pasha 10031947532846001723 10031947532846001723 No Taleghani Hospital, Golestan University of Medical Sciences, Gorgan, Iran