%0 Journal Article %A Azarhoush, Ramin %A Cheraghali, Roozbeh %A Saffarian, Mohammad Sadegh %A Mehravar, Fatemeh %T Expression of Bcl-2 and p53 protein in Stomach Cancer Patients and Association with Clinicopathological Factors %J Journal of Clinical and Basic Research %V 1 %N 3 %U http://jcbr.goums.ac.ir/article-1-70-en.html %R 10.18869/acadpub.jcbr.1.3.1 %D 2017 %K Stomach cancer, P53protein, Bcl-2 protein, Expression, Immunohistochemistry (IHC), %X Introduction: Stomach cancer is one of the most common cancers worldwide. Bcl-2 and p53 appear to be important biomarkers in patients with stomach cancer. In this study, we investigated the expression of Bcl-2 and p53 proteins and its association with clinicopathological factors in 67 Iranian stomach cancer patients over a 5-year period (2010-2015). Material and Methods: In this cross sectional study, the expression of the Bcl-2 and p53 protein was determined using immunohistochemistry, and the pathological features of tumors were evaluated. Results: The expression of Bcl-2 and p53 proteins was detected in 47% and 48% of the patients, respectively. Of the 67 patients, 39 patients had intestinal-type gastric adenocarcinoma, and 57 patients had grade І and ΙΙ. There was a statistically significant association between Bcl-2 and p53 expressions (P=0.04). Conclusions: There is an association between Bcl-2 and p53 protein expressions in patients with stomach cancer. Bcl-2 and p53 protein expressions are more frequent in high-grade tumors. Bcl-2 and p53 expression might play an important role in the early development and phenotypic differentiation of gastric carcinomas, but not so in tumor progression. %> http://jcbr.goums.ac.ir/article-1-70-en.pdf %P 1-7 %& 1 %! %9 Research %L A-10-55-2 %+ %G eng %@ %[ 2017