Volume 2, Issue 4 (Journal of Clinical and Basic Research(JCBR) 2018)                   jcbr 2018, 2(4): 54-59 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Cheraghali F, Hajimoradloo N, Roshandel G, Meftah M, Azadfar S. Prevalence of Kawasaki Disease in Children Admitted to Taleghani Medical Center in Gorgan, Iran. jcbr 2018; 2 (4) :54-59
URL: http://jcbr.goums.ac.ir/article-1-167-en.html
1- Infectious Diseases Research Centre; Golestan University of Medical Sciences, Gorgan, Iran
2- Golestan Research Center of Gastroenterology and Hepatology (GRCGH); Golestan University of Medical Sciences, Gorgan, Iran
Abstract:   (4591 Views)
Background and objectives: Kawasaki disease is an acute systemic vasculitis with an unknown etiology that mainly affects infants and children under five years of age. The aim of this study was to investigate the epidemiology of this disease in the Golestan Province, northeast of Iran.
Methods: In this descriptive-analytical study, we evaluated all patients admitted to the Taleghani Hospital in Gorgan (capital of the Golestan Province) from September 2005 to September 2012. Characteristics of patients who met the diagnostic criteria of Kawasaki disease were recorded.
Results: Overall, 58 children (36 males and 12 females) with Kawasaki disease were included in the study. Thirty-six patients (62.06%) were under 2 years of age and the rest were over 2 years of age. The annual incidence of Kawasaki disease in the studied population was 37.39 per 100,000 children. The most common clinical manifestations were rash (68.6%) and oral mucosal changes (60.8%). The most common laboratory findings were leukocytosis (37.3%), positive C-reactive protein (88.2%), erythrocyte sedimentation rate of >35 (74.5%) and anemia (68.6%). Among 37 cases who were subjected to sonography, one case was found with splenomegaly.
Conclusion: In this areas, Kawasaki disease is more common among children under the age of 2 years. The most common clinical manifestations of the disease are rash and oral mucosal changes.
Full-Text [PDF 389 kb]   (1536 Downloads)    
Article Type: Research | Subject: Medicine

1. Shulman ST. Unclassified infectious diseases. In: Feigin RD, Cherry JD. Text book of pediatric infectious disease. Philadelphia: W.B. Saunders Co 2004; 1.
2. Kordidarian R, Kazemi A, Nikyar A, et al. Assessing Kawasaki disease in children at Alzahra hospital (1995-1999). The Journal of Qazvin Univ. of Med. Sci. 2008; 11(4):42-47. [In Persian]
3. Burgner D, Harnden A. Kawasaki disease: What is the epidemiology telling us about the etiology?. Int J Infect Dis .2005; 9(4): 185-194. [DOI:10.1016/j.ijid.2005.03.002]
4. Rezai M, Siadati S, Khotaei G, et al . Isolation of Kawasaki disease-associated with bacterial sequence from peripheral blood leukocytes. J Mazandaran Univ Med Sci. 2008; 18 (64) :22-28. [In Persian]
5. Mosaiebi Z, Movahedian A, Heidarzadeh M, et al. Evaluation of clinical and paraclinical findings of Kawazaki patients among children admitted in Kashan Shahid Beheshti hospital during 1998-2008. Journal of Kashan University of Medical Sciences (FEYZ). 2010; 14 (3): 249-255. [In Persian]
6. Golestan M, Bahjati M, Akhavan- karbasi S, et al. Review of Kawasaki Patients in Yazd. JSSU. 2009; 16 (4) :21-25. [In Persian]
7. Burns JC, Glodé MP. Kawasaki syndrome. Lancet 2004;364(9433):533-44. [DOI:10.1016/S0140-6736(04)16814-1]
8. Rahbari-Manesh A, Salamati P, Ghaforian S, et al. Relationship between ESR, CRP, platelet count and coronary artery disease in Kawasaki disease. Iranian Journal of Pediatrics 2005; 15(2):139-144.[In Persian]
9. Ayazi P, Mohammadzadeh G, Arian far F. Clinical symptoms and laboratory findings of Kawasaki disease in children. The Journal of Qazvin University of Medical Sciences. 2007; 11 (1) :28-33. [In Persian]
10. Jeong EJ, Park HJ. Clinical Analysis of AtypicaKawasaki Disease: Comparison of Kawasaki Disease Between Typical and Atypical Types. J KoreanPediatr Soc. 2001; 44(12): 1448-53.
11. Singh GD, Wong M, Issacs D. Diagnosis,treatment and outcome of Kawasaki disease in an Australian tertiary setting: A review of three years experience. J Pediatr Child Health. Cardiol 1997;6: 181-5.
12. Nakamura Y, Yashiro M, Uehara R, et al. Use of laboratory data to identify risk factors of giant coronary aneurysms due to Kawasaki disease. Pediatr Int; 2004 ; 46(1): 33-8. [DOI:10.1111/j.1442-200X.2004.01840.x]
13. Yoshikawa H, Abe T. Febrile convulsion during the acute phase of Kawasaki disease. Pediatr Int; 2004. 46(1): 31-2. [DOI:10.1111/j.1442-200X.2004.01850.x]
14. De Zorzi A, Colan SD, Gauvreau K et al. Coronary artery dimensions may be misclassified as normal in Kawaski disease. Journal of Pediatrics.1998; 133(2):254-58. [DOI:10.1016/S0022-3476(98)70229-X]
15. Kasiri K, Khoshdel A, Mokhtariyan K. A case report: An atypical Kawasaki syndrome following aseptic meningitis in a 9-month old infant . J Shahrekord Univ Med Sci. 2008; 10 (3) :90-94. [In Persian]
16. Park Y, Kim C, Han J, Lee J, et al. Epidemiological features of Kawasaki disease in Korea, 2006–2008. Pediatrics International. 2011; 53(1): 36–39. [DOI:10.1111/j.1442-200X.2010.03178.x]
17. Yim D, Burgner D, Cheung M. Echocardiography in Kawasaki Disease.(2012) Echocardiography - In Specific Diseases. 2012. In Tech. [DOI:10.5772/32175]
18. Zhang X, Sun J, Zhang Z, Liu Sh. Epidemiologic Survey of Kawasaki Disease in Jilin from 1999 Through 2008. Pediatr Cardiol. 2012; 33(2):272–279. [DOI:10.1007/s00246-011-0121-7]
19. Harnden A, Takahashi M, Burgner, D. Kawasaki disease. BMJ. 2009; 5(338): 1514. [DOI:10.1136/bmj.b1514]
20. Durongpisitkul K, Sangtawesin Ch, Khongphatthanayopthin A, et al. Epidemiologic Study of Kawasaki Disease and Cases Resistant to IVIG Therapy in Thailand. Asian pacific journal of allergy and immunology. 2006; 24(1): 27-32.
21. YM N, RYT S,LY S, NC F, et al. Kawasaki disease in Hong Kong,1994 to 2000. Hong Kong Med J. 2005; 11(5): 331-335.
22. Gheini S, Hemati M, Arghavanifard P. Characteristics of Kawasaki patients in Kermanshah Hospitals during 1997-2000 .Behbood. 2004; 8(3): 51-62.
23. Mahmoudzadeh H, Nikibakhsh AA, Gheibi SS, et al. A survey on kawasaki disease in imam khomeini hospital, Urmia. Urmia medical journal. 2008; 19 (3) :236-241. [In Persian]
24. Bahatnagar SK, Paul G, Subramanina R, et al. Kawazaki disease in Oman-a clinical study. J Trop Pediatr 2003; 49:361-6. [DOI:10.1093/tropej/49.6.361]
25. Mansouri M, Ghotbi N, Naderi B. Reports of children with kawasaki disease hospitalized in pediatric. Behbood 2009;13(1): 84-91. [In Persian]
26. Sadeghi E., Amin R., Ajamee GH. Kawasaki syndrome: the Iranian experience, Eastern Mediterranean Health J, 2001, 7(1-2): 16-25.

Add your comments about this article : Your username or Email:

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Journal of Clinical and Basic Research

Designed & Developed by : Yektaweb

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0).