en Pediatrics پژوهشي Research <div style="text-align: left;"></div> <div style="text-align: left;">&nbsp;</div> <div style="text-align: left;"></div> <div><span style="font-size:12px;"><span style="font-family:Times New Roman;"><b>Background:</b> The onset of obesity-associated renal injury is insidious and asymptomatic. Therefore, finding an early marker will be extremely useful in its detection. Kidney injury molecule-1 (KIM-1) can be evaluated as an early marker for renal injury in obese children.<br> <b>Methods:</b> This case control study involved two groups: a case group of 45 Egyptian overweight/obese children and a control group of 45 non-obese peers. Anthropometry and blood pressure were measured in both groups. Additionally, KIM-1 and serum creatinine levels were assessed.<br> <b>Results:</b> Compared to the control group, the case group showed a significantly higher systolic (P-value 0.000) and diastolic (P-value 0.002) blood pressure. A significantly higher serum creatinine (P=0.007) and KIM-1 (P=0.001) were also found.<br> <b>Conclusion</b>: It is inferred that obesity impacts renal hemodynamics early in childhood. Thus, identifying a screening marker like KIM-1 is useful for the early diagnosis of renal injury.</span></span><br> &nbsp;</div> Adolescents, Obesity, KIM-1 protein, Renal Injury, 17 19 http://jcbr.goums.ac.ir/browse.php?a_code=A-10-437-1&slc_lang=en&sid=1 Nermine Nabil Mahfouz 10031947532846005548 10031947532846005548 No Department of Child Health, Medical Research and Clinical Studies Institute, Medical Research Centre of Excellence (MRCE), National Research Centre, Cairo, Egypt Azza Abd El-Shaheed 10031947532846005549 10031947532846005549 No Department of Child Health, Medical Research and Clinical Studies Institute, Medical Research Centre of Excellence (MRCE), National Research Centre, Cairo, Egypt Sara Fawzy Sallam lara26sara@gmail.com 10031947532846005550 10031947532846005550 Yes Department of Child Health, Medical Research and Clinical Studies Institute, Medical Research Centre of Excellence (MRCE), National Research Centre, Cairo, Egypt Rehab Selim Ismail Moustafa 10031947532846005551 10031947532846005551 No Department of Child Health, Medical Research and Clinical Studies Institute, Medical Research Centre of Excellence (MRCE), National Research Centre, Cairo, Egypt Salwa Refaat El-Zayat 10031947532846005552 10031947532846005552 No Physiology Department, Medical Research and Clinical Studies Institute, Medical Research Centre of Excellence (MRCE), National Research Centre, Cairo, Egypt Hiba Sibaii 10031947532846005553 10031947532846005553 No Physiology Department, Medical Research and Clinical Studies Institute, Medical Research Centre of Excellence (MRCE), National Research Centre, Cairo, Egypt