en Medicine گزارش مورد Case report <div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:150%"><span calibri="" style="font-family:"><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Sickle cell disease(SCD) is a hemoglobinopathy characterized by chronic hemolyticanemia and vaso-occlusive painful crisis. The vascular occlusion in SCD is a complex process that is responsible for most clinical manifestations of the disease. Abdominal pain is an important component of vaso-occlusive painful crisis and may mimic diseases, such as acute appendicitis and cholecystitis. Acute pancreatitis is rarely encountered as a cause of abdominal pain in patients with SCD. Gallstones and alcohol abuse account for the majority of the cases of acute pancreatitis. Pancreatic ischemia is an uncommon but established cause of pancreatitis associated with connective tissue diseases, vasculitis, and shock. In SCD, the deformed red blood cellsresulting from deoxygenation during stress, infection or dehydration, cause vaso-occlusion, tissue ischemia, and infarction. We present a case of SCDpresenting as acute pancreatitis apparently due to microvascular occlusion and ischemic injury to the pancreas. The patient responded to conservative management. Our case will help to always keep in mind and consider acute pancreatitis as a differential diagnosis in patients with SCD presenting with abdominal pain. </span></span></span></span></span></span><br> &nbsp;</div> Acute pancreatitis, Sickle cell disease, vaso-occlusive painful crisis 31 35 http://jcbr.goums.ac.ir/browse.php?a_code=A-10-211-2&slc_lang=en&sid=1 Deebyendu Sahu deebyendu95@gmail.com 10031947532846003886 10031947532846003886 No PG Department of Medicine, SCBMedical College, Cuttack, India Smrutisamikshya Nayak ayhskimas@gmail.com 10031947532846003887 10031947532846003887 No PG Department of Medicine, SCBMedical College, Cuttack, India NiharRanjan Mohanty drnihar123@yahoo.com 10031947532846003888 10031947532846003888 Yes PG Department of Medicine, SCBMedical College, Cuttack, India Bhagyashree panda dr.bhagyashree.panda@gmail.com 10031947532846003889 10031947532846003889 No PG Department of Medicine, SCBMedical College, Cuttack, India