en Microbiology مروری Review <div style="text-align: justify;">Tuberculosis (TB) has infected billions of people worldwide. The clinical appearance of TB is close to that of Coronavirus disease 2019 (COVID-19). Active pulmonary TB infection can lead to severe pulmonary distress syndrome. Recent studies have revealed the clinical significance of TB surveillance in COVID-19 patients. In this mini-review, we compiled data from published literature and addressed the significance of interplay between TB and SARS-CoV-2 co-infection. Bilateral cross-relationship between these two major public health issues can be classified into two main categories. On one hand, active TB and multidrug-resistance infections lead to poor prognosis, particularly in elderly patients with COVID-19. On the other hand, the SARS-CoV-2 pandemic caused major harm to the global TB services and surveillance.</div> SARS-CoV-2, Tuberculosis, Prognosis 33 39 http://jcbr.goums.ac.ir/browse.php?a_code=A-10-88-8&slc_lang=en&sid=1 Mohsen Ebrahimi m1355ebrahimi@gmail.com 10031947532846003544 10031947532846003544 No Children's Research Center, Golestan University of Medical Sciences, Gorgan, Iran Fatemeh Sana Askari Pari.askari1212@yahoo.com 10031947532846003545 10031947532846003545 No Department of Microbiology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran Nazanin Razzaghi nazaninrazaghi7413@gmail.com 10031947532846003546 10031947532846003546 No Children's Research Center, Golestan University of Medical Sciences, Gorgan, Iran Alireza Mohebbi mohebbi-a@goums.ac.ir 10031947532846003547 10031947532846003547 Yes Vista Aria Rena Gene Inc/Department of Microbiology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran