Journal of Clinical and Basic Research
Journal of Clinical and Basic Research
jcbr
Medical Sciences
http://jcbr.goums.ac.ir
1
admin
2538-3736
10.52547/jcbr
en
jalali
1397
5
1
gregorian
2018
8
1
2
2
online
1
fulltext
en
Serum Concentrations of Trace Elements in Patients with Ulcerative Colitis
Medicine
پژوهشي
Research
<div style="text-align: justify;"><strong>Introduction:</strong> Nutritional status of patients with inflammatory bowel disease is estimated to be lower than optimal. This study was designed to compare the serum level of some trace elements in patients with ulcerative colitis (UC). <strong>Materials and methods: </strong>This cross-sectional study was performed in 2015-2016, on 60 recently diagnosed UC patients (30 with active UC and 30 with inactive UC) who were recruited from registry of the Golestan Research Center of Gastroenterology and Hepatology (Gorgan, Iran) through simple random sampling. Thirty healthy individuals were also recruited as controls. Demographic data and disease activity index were recorded through a checklist. Serum levels of copper (Cu), zinc (Zn), selenium (Se) and magnesium (Mg) were measured by atomic absorption spectroscopy. Data were analyzed using SPSS 16 at significance level of 0.05. <strong>Results: </strong>Mean serum level of Cu in the patients (0.75±0.25 mg/L) was significantly lower than in the controls (1.11±0.3 mg/L) (P=0001). Similarly, mean serum level of Mg in the patients (15.84±4.3 mg/L) was significantly lower than in the controls (19.48±15.7 mg/L) (P=0.001). Mean serum level of Se was slightly higher among the UC patients, while mean serum level of Zn was slightly lower in the UC patients compared with the controls. <strong>Conclusions: </strong>Our results show that UC patients have significantly lower Cu and Mg levels compared to healthy individuals. However, serum Zn and Se levels do not differ significantly between the UC patients and the control individuals. Further studies are required to confirm the results of this study.</div>
Inflammatory bowel diseases, Ulcerative colitis, Trace elements
40
45
http://jcbr.goums.ac.ir/browse.php?a_code=A-10-100-2&slc_lang=en&sid=1
Hamidreza
Joshaghani
حمیدرضا
جوشقانی
10031947532846001709
10031947532846001709
Yes
Golestan University of Medical Sciences, Gorgan, Iran
Taghi
Amiriani
تقی
امیریانی
10031947532846001710
10031947532846001710
No
Golestan University of Medical Sciences, Gorgan, Iran
Reza
Goodarzi
رضا
گودرزی
10031947532846001711
10031947532846001711
No
Golestan University of Medical Sciences, Gorgan, Iran
Honeyeh-sadat
Mirkarimi
هانیه سادات
میرکریمی
10031947532846001712
10031947532846001712
No
Golestan University of Medical Sciences, Gorgan, Iran
Sima
Besharat
سیما
بشارت
10031947532846001713
10031947532846001713
No
Golestan University of Medical Sciences, Gorgan, Iran
Gholamreza
Roshandel
غلامرضا
روشندل
10031947532846001714
10031947532846001714
No
Golestan University of Medical Sciences, Gorgan, Iran
Bahar
Kolasangiani
بهار
کلاسنگیانی
10031947532846001715
10031947532846001715
No
Infectious Disease Research Center, Golestan University of Medical Sciences, Golestan, Iran
Samaneh Sadat
Aghili
سمانه سادات
عقیلی
10031947532846001716
10031947532846001716
No
Infectious Disease Research Center, Golestan University of Medical Sciences, Golestan, Iran