AU - Arab Zoozani, Mahdi AU - Ghaemi, Ezzat Allah AU - Jamalli, Ailar TI - Frequency of AmpC β-lactamase Resistance in Escherichia coli Isolates from Urinary Tract Infections in Gorgan, Iran PT - JOURNAL ARTICLE TA - Journal-of-Clinical-and-Basic-Research-_YW_PAR_OPEN_JCBR_YW_PAR_CLOSE_ JN - Journal-of-Clinical-and-Basic-Research-_YW_PAR_OPEN_JCBR_YW_PAR_CLOSE_ VO - 1 VI - 4 IP - 4 4099 - http://jcbr.goums.ac.ir/article-1-96-en.html 4100 - http://jcbr.goums.ac.ir/article-1-96-en.pdf SO - Journal-of-Clinical-and-Basic-Research-_YW_PAR_OPEN_JCBR_YW_PAR_CLOSE_ 4 AB  - Introduction: AmpC β-lactamases are among the most important cephalosporinases. Production of AmpC β-lactamase in microorganisms is often associated with multidrug resistance and limited treatment options. This study aimed to determine antimicrobial susceptibility pattern and frequency of AmpC β-lactamase genes in Escherichia coli strains isolated from urinary tract infections. Materials and Methods: The study included 154 E. coli isolates from urine samples of patients in medical centers of Gorgan, Iran. Cefoxitin-resistance was evaluated by the Kirby-Bauer method. Cefoxitin-resistant strains were evaluated using cefoxitin disks alone and combined with boronic acid to confirm presence of AmpC β-lactamase. Presence of MOX gene was investigated by polymerase chain reaction. Results: Among the 154 E. coli isolates, 37 (24%) were cefoxitin-resistant, 16 of which were found to be AmpC β-lactamase-positive in the phenotypic test. In addition, the MOX gene was found in two isolates. Conclusions: The frequency of AmpC β-lactamase-producing E. coli and MOX gene in Gorgan is close to the regional and national average. CP - IRAN IN - LG - eng PB - Journal-of-Clinical-and-Basic-Research-_YW_PAR_OPEN_JCBR_YW_PAR_CLOSE_ PG - 1 PT - Research YR - 2017