@ARTICLE{Sepehri, author = {Margdari, Asra and Ebrahimi, Soheila and Sepehri, Hamid and }, title = {Effect of Simvastatin on Spatial Memory of Rats Receiving a High-Fat Diet}, volume = {1}, number = {2}, abstract ={Introduction: Several studies have demonstrated the role of high cholesterol in different diseases. A diet high in cholesterol or saturated fats can impair the cognitive function. The aim of this study was to investigate the impact of simvastatin on spatial memory of rats receiving a high-fat diet. Materials and Methods: In this study, 35 adult male Wistar rats were divided into five groups (N=7). The subjects were trained for five days four times a day in Morris water maze to find a hidden platform. Time elapsed and distance travelled for finding the hidden platform were considered as criteria for learning. Probe trial was used for evaluation of memory retrieval. Results: Consumption of high fat diet for four weeks reduced learning ability in the high-fat group, which spent longer time and travelled a longer distance compared to the control group. However, oral administration of simvastatin at doses of 5 and 10 mg improved memory function. Memory function in rats treated with the drug had a significant difference with that of in the high-fat group. However, no significant difference was found between the groups treated with different doses of simvastatin. Conclusions: simvastatin improves spatial memory performance in adult male rats receiving high-fat diet. }, URL = {http://jcbr.goums.ac.ir/article-1-55-en.html}, eprint = {http://jcbr.goums.ac.ir/article-1-55-en.pdf}, journal = {Journal of Clinical and Basic Research}, doi = {}, year = {2017} }