:: Volume 1, Issue 3 (Journal of Clinical and Basic Research(JCBR) 2017) ::
jcbr 2017, 1(3): 1-7 Back to browse issues page
Expression of Bcl-2 and p53 protein in Stomach Cancer Patients and Association with Clinicopathological Factors
Ramin Azarhoush , Roozbeh Cheraghali , Mohammad Sadegh Saffarian , Fatemeh Mehravar
Abstract:   (534 Views)
Introduction: Stomach cancer is one of the most common cancers worldwide. Bcl-2 and p53 appear to be important biomarkers in patients with stomach cancer. In this study, we investigated the expression of Bcl-2 and p53 proteins and its association with clinicopathological factors in 67 Iranian stomach cancer patients over a 5-year period (2010-2015). Material and Methods: In this cross sectional study, the expression of the Bcl-2 and p53 protein was determined using immunohistochemistry, and the pathological features of tumors were evaluated. Results: The expression of Bcl-2 and p53 proteins was detected in 47% and 48% of the patients, respectively. Of the 67 patients, 39 patients had intestinal-type gastric adenocarcinoma, and 57 patients had grade І and ΙΙ. There was a statistically significant association between Bcl-2 and p53 expressions (P=0.04). Conclusions: There is an association between Bcl-2 and p53 protein expressions in patients with stomach cancer. Bcl-2 and p53 protein expressions are more frequent in high-grade tumors. Bcl-2 and p53 expression might play an important role in the early development and phenotypic differentiation of gastric carcinomas, but not so in tumor progression.
Keywords: Stomach cancer, P53protein, Bcl-2 protein, Expression, Immunohistochemistry (IHC)
Full-Text [PDF 374 kb]   (166 Downloads)    
Type of Study: Research | Subject: Genaral
Received: 2017/07/25 | Accepted: 2017/11/20 | Published: 2017/11/28
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Volume 1, Issue 3 (Journal of Clinical and Basic Research(JCBR) 2017) Back to browse issues page