Volume 2, Issue 2 (Journal of Clinical and Basic Research(JCBR) 2018)
jcbr 2018, 2(2): 40-45 |
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Hamidreza Joshaghani * 
1, Taghi Amiriani1 , Reza Goodarzi1 , Honeyeh-sadat Mirkarimi1 , Sima Besharat1 , Gholamreza Roshandel1 , Bahar Kolasangiani2 , Samaneh Sadat Aghili2
1, Taghi Amiriani1 , Reza Goodarzi1 , Honeyeh-sadat Mirkarimi1 , Sima Besharat1 , Gholamreza Roshandel1 , Bahar Kolasangiani2 , Samaneh Sadat Aghili2
1- Golestan University of Medical Sciences, Gorgan, Iran
2- Infectious Disease Research Center, Golestan University of Medical Sciences, Golestan, Iran
2- Infectious Disease Research Center, Golestan University of Medical Sciences, Golestan, Iran
Abstract: (3702 Views)
Introduction: Nutritional status of patients with inflammatory bowel disease is estimated to be lower than optimal. This study was designed to compare the serum level of some trace elements in patients with ulcerative colitis (UC). Materials and methods: This cross-sectional study was performed in 2015-2016, on 60 recently diagnosed UC patients (30 with active UC and 30 with inactive UC) who were recruited from registry of the Golestan Research Center of Gastroenterology and Hepatology (Gorgan, Iran) through simple random sampling. Thirty healthy individuals were also recruited as controls. Demographic data and disease activity index were recorded through a checklist. Serum levels of copper (Cu), zinc (Zn), selenium (Se) and magnesium (Mg) were measured by atomic absorption spectroscopy. Data were analyzed using SPSS 16 at significance level of 0.05. Results: Mean serum level of Cu in the patients (0.75±0.25 mg/L) was significantly lower than in the controls (1.11±0.3 mg/L) (P=0001). Similarly, mean serum level of Mg in the patients (15.84±4.3 mg/L) was significantly lower than in the controls (19.48±15.7 mg/L) (P=0.001). Mean serum level of Se was slightly higher among the UC patients, while mean serum level of Zn was slightly lower in the UC patients compared with the controls. Conclusions: Our results show that UC patients have significantly lower Cu and Mg levels compared to healthy individuals. However, serum Zn and Se levels do not differ significantly between the UC patients and the control individuals. Further studies are required to confirm the results of this study.
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