Volume 2, Issue 1 ((Journal of Clinical and Basic Research(JCBR) 2018)
jcbr 2018, 2(1): 26-31 |
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Ghari Arab A, Zahedi M, Kazemi Nejad V, Sanagoo A, Azimi M. Correlation between Hemoglobin A1c and Serum Lipid Profile in Type 2 Diabetic Patients Referred to the Diabetes Clinic in Gorgan, Iran. jcbr 2018; 2 (1) :26-31
URL: http://jcbr.goums.ac.ir/article-1-134-en.html
URL: http://jcbr.goums.ac.ir/article-1-134-en.html
Abstract: (6342 Views)
Introduction: Hyperlipidemia is a common risk factor for diabetes and its cardiovascular complications. The aim of this study was to investigate the association between hemoglobin A1c (HbA1c) levels and serum lipids in patients with type 2 diabetes. Materials and Methods: This descriptive-analytical and cross-sectional study was conducted in 2016 on 484 patients with type 2 diabetes referred to the Diabetes Clinic in Gorgan, Iran. Blood samples were taken from all patients and sent to laboratory for measurement of HbA1c, FBS and serum lipids. Data were collected via registration forms. The data were analyzed with SPSS software (version 20) using independent t-test, Mann-Whitney U test and Pearson’s and Spearman’s coefficient tests. Results: Mean age of subjects was 56.61 ± 12.65 years with age range of 17 to 92 years. Mean duration of the disease was 13.52 ± 7.55 years (range: 1-44 years). Mean HbA1c level was 8.83 ± 1.8 mg/dl. There was a statistically significant correlation between HbA1c level and serum cholesterol (P=0.001), triglyceride (P=0.009), low-density lipoprotein (P=0.003) and FBS (P=0.0001). However, there was no statistically significant relationship between HbA1c and high-density lipoprotein levels (P= 0.8). Conclusions: High level of HbA1C is associated with dyslipidemia and can be used as predictors of cardiovascular disease in type 2 diabetes patients.
Article Type: Research |
Subject:
Statistics and epidemiology
References
1. Saeed KMI, Asghar RJ, Sahak MN, Ansari J. Prevalence and risk factors associated with diabetes mellitus among Kabul citizens—Afghanistan, 2012. International Journal of Diabetes in Developing Countries. 2015;35(3):297-303. [DOI:10.1007/s13410-014-0270-3]
2. Ghaemi N, Vakili R. Evaluation of lipids level and its relation to HbA1C in diabetic children. Iranian journal of pediatrics. 2005;15(2):111-7.
3. VinodMahato R, Gyawali P, Raut PP, Regmi P, Singh KP, Pandeya DR, et al. Association between glycaemic control and serum lipid profile in type 2 diabetic patients: Glycated haemoglobin as a dual biomarker. Biomedical research. 2011; 22(3).
4. Saydah SH, Miret M, Sung J, Varas C, Gause D, Brancati FL. Postchallenge hyperglycemia and mortality in a national sample of US adults. Diabetes care. 2001;24(8):1397-402. [DOI:10.2337/diacare.24.8.1397]
5. Baranwal JK, Maskey R, Majhi S, Lamsal M, Baral N. Association between level of HbA1c and lipid profile in T2DM patients attending diabetic OPD at BPKIHS. Health Renaissance. 2017;13(3):16-23. [DOI:10.3126/hren.v13i3.17923]
6. Mostafa S, Coleman R, Agbaje O, Gray A, Holman R, Bethel M. Modelling incremental benefits on complications rates when targeting lower HbA1c levels in people with Type 2 diabetes and cardiovascular disease. Diabetic Medicine. 2018;35(1):72-7. [DOI:10.1111/dme.13533]
7. Ravipati G, Aronow WS, Ahn C, Sujata K, Saulle LN, Weiss MB. Association of hemoglobin A1c level with the severity of coronary artery disease in patients with diabetes mellitus. American journal of cardiology. 2006;97(7):968-9. [DOI:10.1016/j.amjcard.2005.10.039]
8. Gardiner HM, Pasquini L, Wolfenden J, Kulinskaya E, Li W, Henein M. Increased periconceptual maternal glycated haemoglobin in diabetic mothers reduces fetal long axis cardiac function. Heart. 2006;92(8):1125-30. [DOI:10.1136/hrt.2005.076885]
9. Selvin E, Wattanakit K, Steffes MW, Coresh J, Sharrett AR. HbA1c and peripheral arterial disease in diabetes: the Atherosclerosis Risk in Communities study. Diabetes care. 2006;29(4):877-82. [DOI:10.2337/diacare.29.04.06.dc05-2018]
10. KAWASUMI M, TANAKA Y, UCHINO H, SHIMIZU T, TAMURA Y, SATO F, et al. Strict glycemic control ameliorates the increase of carotid IMT in patients with type 2 diabetes. Endocrine journal. 2006;53(1):45-50. [DOI:10.1507/endocrj.53.45]
11. Khan H, Sobki S, Khan S. Association between glycaemic control and serum lipids profile in type 2 diabetic patients: HbA 1c predicts dyslipidaemia. Clinical and experimental medicine. 2007;7(1):24-9. [DOI:10.1007/s10238-007-0121-3]
12. KERAMATI MR, Sadeghian M, PARIZADEH S, MAROUZI F. ASSOCIATION BETWEEN THE LEVEL OF HBA1C & SERUM LIPIDS PROFILE IN TYPE 2 DIABETIC PATIENTS. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES. 2008;51(3):159-164
13. Samatha P, Prabodh V, Chowdary N, Shekhar R. Glycated hemoglobin and serum lipid profile associations in type 2 diabetes mellitus patients. J Pharmac Biomed Sci. 2012;17(17):1-4.
14. Hassan DA, Elhussein AB, Fadlelseed OE, Babikr WG, Idris OF. Lipid profile and glycated hemoglobin (HbA1c) in diabetic Sudanese patients. International Journal of Science and Research. 2015;4(2):1813-16.
15. Pujari SS. HbA1c as marker of dyslipidemia in type 2 diabetes mellitus patients. Sch J App Med Sci. 2013;1(6):728-31.
16. Al-Alawi SA. Serum lipid profile and glycated hemoglobin status in Omani patients with type2 diabetes mellitus attending a primary care polyclinic. Biomedical Research. 2014;25(2).
17. Singh G, Kumar A. Relationship among HbA1c and lipid profile in Punajbi type 2 diabetic population. Journal of Exercise Science and Physiotherapy. 2011;7(2):99. [DOI:10.18376//2011/v7i2/67614]
18. Parial CHR, Islam M, Ahmad M, Kasru A. Association of HbA1c, creatinine and lipid profile in patients with diabetic foot ulcer. Middle-East Journal of Scientific Research. 2013;16(11):1508-11.
19. Raja Reddy R, Jayarama N, Shashidhar K. Association among HbA1c and lipid profile in Kolar type 2 diabetic population. Journal of Pharmaceutical and Scientific Innovation. 2013;2:10-2. [DOI:10.7897/2277-4572.02685]
20. Sreenivas R, Meera S, Ebenezer W. Correlation between glycemic control and lipid profile in type 2 diabetic patients: HbA1c as an indicatior of dyslipidemia. Asian J Pharm Clin Res. 2014;7:153-5.
21. Mahajan R, Koley S. Association of HbA1c with lipid profiles in patients with type 2 diabetes mellitus. International Journal of Biomedical Research. 2016;7:139-43.
22. Naeem M, Khattak RM, ur Rehman M, Khattak MNK. The role of glycated hemoglobin (HbA1c) and serum lipid profile measurements to detect cardiovascular diseases in type 2 diabetic patients. South East Asia Journal of Public Health. 2016;5(2):30-4. [DOI:10.3329/seajph.v5i2.28310]
23. Ismail I, Nazaimoon W, Mohamad W, Letchuman R, Singaraveloo M, Hew F, et al. Ethnicity and glycaemic control are major determinants of diabetic dyslipidaemia in Malaysia. Diabetic Medicine. 2001;18(6):501-8. [DOI:10.1046/j.1464-5491.2001.00494.x]
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0).