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:: Volume 2, Issue 1 ((Journal of Clinical and Basic Research(JCBR) 2018) ::
jcbr 2018, 2(1): 11-15 Back to browse issues page
Characterization of Gastrointestinal Human Cytomegalovirus Infection in Biopsy Samples from Urease Positive Patients
Mojtaba Pourmomen1, Alireza Mohebbi2, Hanieh Bagheri3, Alireza Nourozi4 , Alireza Tahamtan5, Mohammad Yasaghi2, Hamidreza Pordeli1, Alijan Tabarraei * 3
1- Department of Microbiology, Islamic Azad University, Gorgan branch, Gorgan, Iran
2- Student Research Committee, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
3- Infectious Diseases Research Centre, Golestan University of Medical Science, Gorgan, Iran
4- Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran
5- Golestan University of Medical Sciences, Gorgan, Iran
Abstract:   (871 Views)
Human cytomegalovirus (CMV) isa ubiquitous organism thatcan infect multiple organs butrarely causes gastrointestinal (GI) symptoms. However, it can be reactivated in the GI tractand lead to gastric cancer. Here, we investigatedCMV infection in patients with gastric complaints.Material and methods:In this study,99 biopsy samples were collected from patientswith GI symptoms and CMV genome was detected by polymerase chain reaction. Sequencing was performed for computational genotyping.Results:We observed that 88.99% of the sampleswere urease positive and 5.99% of the sampleswere CMV positive. Moreover, genotype of the samples belonged to group 4 (gB4). There was a relatively high incidence of CMV infection in patients with GI problems. Conclusions:Although symptomatic CMV-associated diseases of GI tract are rare in immunocompetent individuals, theymight be considered as potential complications of CMV infection.
Keywords: Human cytomegalovirus, Gastrointestinal infection, Gastric biopsy, Urease positive
Full-Text [PDF 157 kb]   (186 Downloads)    
Article Type: Research | Subject: Statistics and epidemiology
Received: 2018/05/9 | Accepted: 2018/05/9 | Published: 2018/05/9
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Pourmomen M, Mohebbi A, Bagheri H, Nourozi A, Tahamtan A, Yasaghi M, et al . Characterization of Gastrointestinal Human Cytomegalovirus Infection in Biopsy Samples from Urease Positive Patients. jcbr. 2018; 2 (1) :11-15
URL: http://jcbr.goums.ac.ir/article-1-122-en.html


Volume 2, Issue 1 ((Journal of Clinical and Basic Research(JCBR) 2018) Back to browse issues page
Journal of Clinical and Basic Research Journal of Clinical and Basic Research
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