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:: Volume 1, Issue 2 ((Journal of Clinical and Basic Research (JCBR) 2017) ::
jcbr 2017, 1(2): 21-28 Back to browse issues page
Effect of Simvastatin on Spatial Memory of Rats Receiving a High-Fat Diet
Asra Margdari , Soheila Ebrahimi , Hamid Sepehri
Abstract:   (600 Views)

Introduction: Several studies have demonstrated the role of high cholesterol in different diseases. A diet high in cholesterol or saturated fats can impair the cognitive function. The aim of this study was to investigate the impact of simvastatin on spatial memory of rats receiving a high-fat diet. Materials and Methods: In this study, 35 adult male Wistar rats were divided into five groups (N=7). The subjects were trained for five days four times a day in Morris water maze to find a hidden platform. Time elapsed and distance travelled for finding the hidden platform were considered as criteria for learning. Probe trial was used for evaluation of memory retrieval. Results: Consumption of high fat diet for four weeks reduced learning ability in the high-fat group, which spent longer time and travelled a longer distance compared to the control group. However, oral administration of simvastatin at doses of 5 and 10 mg improved memory function. Memory function in rats treated with the drug had a significant difference with that of in the high-fat group. However, no significant difference was found between the groups treated with different doses of simvastatin. Conclusions: simvastatin improves spatial memory performance in adult male rats receiving high-fat diet.

Keywords: Spatial memory, Simvastatin, Morris water maze, High-fat diet
Full-Text [PDF 452 kb]   (320 Downloads)    
Type of Study: Research |
Received: 2017/08/12 | Accepted: 2017/08/12 | Published: 2017/08/12
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Margdari A, Ebrahimi S, Sepehri H. Effect of Simvastatin on Spatial Memory of Rats Receiving a High-Fat Diet. jcbr. 2017; 1 (2) :21-28
URL: http://jcbr.goums.ac.ir/article-1-55-en.html


Volume 1, Issue 2 ((Journal of Clinical and Basic Research (JCBR) 2017) Back to browse issues page
Journal of Clinical and Basic Research Journal of Clinical and Basic Research
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