Volume 2, Issue 4 (Journal of Clinical and Basic Research(JCBR) 2018)
jcbr 2018, 2(4): 41-47 |
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Chorli F, Ghodsalavi Z, Hajilari M, Dastaviz F, Mehri M, Oladnabi M. Three Women with Non-Segmental Vitiligo in Three Generations of a Family: A Case Report . jcbr 2018; 2 (4) :41-47
URL: http://jcbr.goums.ac.ir/article-1-169-en.html
URL: http://jcbr.goums.ac.ir/article-1-169-en.html
Fatemeh Chorli1 
, Zahra Ghodsalavi1 , Maryam Hajilari1 , Farzad Dastaviz1 , Majid Mehri2 , Morteza Oladnabi * 3
, Zahra Ghodsalavi1 , Maryam Hajilari1 , Farzad Dastaviz1 , Majid Mehri2 , Morteza Oladnabi * 3
1- Student Research Committee, Golestan University of Medical Sciences, Gorgan, Iran
2- Department of Internal Medicine, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
3- Department of Medical Genetics, Gorgan Congenital Malformations Research Center, Golestan University of Medical Sciences, Gorgan, Iran
2- Department of Internal Medicine, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
3- Department of Medical Genetics, Gorgan Congenital Malformations Research Center, Golestan University of Medical Sciences, Gorgan, Iran
Abstract: (3404 Views)
Background: Vitiligo is a common autoimmune skin disorder, which is characterized by incomplete penetrance and genetic heterogeneity. It is classified into two types: segmental and non-segmental, and most cases suffer from non-segmental vitiligo. The disease affects about 2-10 in 1000 people in different population with no sex predilection. Furthermore, the genetics of vitiligo cannot be described by Mendelian pattern of inheritance. We herein report three female relatives (niece, aunt, grandmother) with non-segmental vitiligo in a family.
Case description: The symptoms and severity of the disease varied between the cases. Incomplete penetrance was completely evident in this family. The grandmother had not received any treatment, but the aunt and niece were receiving medication and phototherapy. However, these treatments were not beneficial for them.
Conclusion: Currently there is no effective treatment or screening method for vitiligo. Thus, genetic counseling, risk determination and identification of other genetic contributors could be beneficial.
Case description: The symptoms and severity of the disease varied between the cases. Incomplete penetrance was completely evident in this family. The grandmother had not received any treatment, but the aunt and niece were receiving medication and phototherapy. However, these treatments were not beneficial for them.
Conclusion: Currently there is no effective treatment or screening method for vitiligo. Thus, genetic counseling, risk determination and identification of other genetic contributors could be beneficial.
References
1. Shah R, Hunt J, Webb TL, Thompson AR. Starting to develop self-help for social anxiety associated with vitiligo: using clinical significance to measure the potential effectiveness of enhanced psychological self-help. Br J Dermatol. 2014;171(2):332-7. [DOI:10.1111/bjd.12990]
2. Saeedinezhad F, Firouzkouhi M, Abdollahimohammad A, Rahnama M. The challenges facing with vitiligo: a phenomenological research. Int. J. Pharm. Res. Allied Sci., 2016, 5(3):356-364.
3. Aghaei S, Amiri M, Aghaei M, Nilforoushzadeh MA. Molecular genetics and epidemiology of vitiligo: a minireview. Int J Epidemiol Res. 2018;5(3):103-106. [DOI:10.15171/ijer.2018.22]
4. 4 .Afkhami-Ardekani M, Ghadiri-Anari A, Ebrahimzadeh-Ardakani M, Zaji N. Prevalence of vitiligo among type 2 diabetic patients in an Iranian population. Int J Dermatol. 2014;53(8):956-8. [DOI:10.1111/ijd.12148]
5. Saeedinezhad F, Firouzkouhi M, Abdollahimohammad A and Rahnama M , Aziz Shahrakivahed A (2017).The Lived Experiences of Persons with Vitiligo: A Phenomenological Research. JAMMR, 2017 23(9): 1-8.
6. Silverberg JI, Silverberg NB. Quality of life impairment in children and adolescents with vitiligo. Pediatr Dermatol. 2014;31(3):309-18. [DOI:10.1111/pde.12226]
7. Cupertino F, Niemeyer-Corbellini JP, Ramos-E-Silva M. Psychosocial effects of vitiligo. Clin Dermatol. 2017;35(3):292-297. [DOI:10.1016/j.clindermatol.2017.01.001]
8. 8 .Spritz R, Andersen G. Genetics of Vitiligo. Dermatol Clin. 2017; 35(2): 245–255. [DOI:10.1016/j.det.2016.11.013]
9. Dicle O. Assessment Methods in Vitiligo. Pigmentary Disorders 2015; 2: 160.
10. Salah Eldin MM, Sami NA, Aly DG, Hanafy NS. Comparison Between (311-312 nm) Narrow Band Ultraviolet-B Phototherapy and (308 nm) Monochromatic Excimer Light Phototherapy in Treatment of Vitiligo: A Histopathological Study. J Lasers Med Sci. 2017; 8(3):123-127. [DOI:10.15171/jlms.2017.22]
11. Ahn Wee MD. A case report of extensive vitiligo. Hawaii Tien- Medical Journal. 1997; 56: 37-42.
12. Pacifico A, Leone G. Photo(chemo)therapy for vitiligo. Photodermatol Photoimmunol Photomed. 2011; 27(5):261-77. [DOI:10.1111/j.1600-0781.2011.00606.x]
13. Singh WG, Gomez AC, Swamy SC, Ashok DN, and Reddy MJ. Approach to a case of vitiligo. Ind J Aerospace Med. 2009; 53(1): 62-65.
14. Manolache L, Petrescu-Seceleanu D. Stress involvement as trigger factor in different skin conditions. World J Dermatol. 2013; 2(3): 16-26. [DOI:10.5314/wjd.v2.i3.16]
15. Pasricha JS, Khaitan BK. Oral mini-pulse therapy with betamethasone in vitiligo patients having extensive or fast-spreading disease. Int J Dermatol. 1993;32(10):753-7. [DOI:10.1111/j.1365-4362.1993.tb02754.x]
16. Kanwar AJ, Dhar S, Dawn G. Oral minipulse therapy in vitiligo. Dermatology. 1995;190(3):251-2. [DOI:10.1159/000246705]
17. Sung JY, Hong JH, Kang HS, Choi I, Lim SD, Lee JK, Seok JH, Lee JH, Hur GM. Methotrexate suppresses the interleukin-6 induced generation of reactive oxygen species in the synoviocytes of rheumatoid arthritis. Immunopharmacology. 2000;47(1):35-44. [DOI:10.1016/S0162-3109(99)00185-X]
18. Singh H, Kumaran MS, Bains A, Parsad D. A Randomized Comparative Study of Oral Corticosteroid Minipulse and Low-Dose Oral Methotrexate in the Treatment of Unstable Vitiligo. Dermatology. 2015;231(3):286-90. [DOI:10.1159/000433424]
19. Silvan M. The psychological aspects of vitiligo. Cutis 2004; 163-167.
20. Papadopoulos L, Bor R, Legg C, Hawk JL. Impact of life events on the onset of vitiligo in adults: preliminary evidence for a psychological dimension in aetiology. Clin Exp Dermatol 1998; 23: 243-248. [DOI:10.1046/j.1365-2230.1998.00384.x]
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