en پژوهشي Research <p><strong>Introduction: </strong>Several studies have demonstrated the role of high cholesterol in different diseases. A diet high in cholesterol or saturated fats can impair the cognitive function. The aim of this study was to investigate the impact of simvastatin on spatial memory of rats receiving a high-fat diet. <strong>Materials and Methods:</strong> In this study, 35 adult male Wistar rats were divided into five groups (N=7). The subjects were trained for five days four times a day in Morris water maze to find a hidden platform. Time elapsed and distance travelled for finding the hidden platform were considered as criteria for learning. Probe trial was used for evaluation of memory retrieval. <strong>Results:</strong> Consumption of high fat diet for four weeks reduced learning ability in the high-fat group, which spent longer time and travelled a longer distance compared to the control group. However, oral administration of simvastatin at doses of 5 and 10 mg improved memory function. Memory function in rats treated with the drug had a significant difference with that of in the high-fat group. However, no significant difference was found between the groups treated with different doses of simvastatin. <strong>Conclusions:</strong> simvastatin improves spatial memory performance in adult male rats receiving high-fat diet.</p> Spatial memory, Simvastatin, Morris water maze, High-fat diet 21 28 http://jcbr.goums.ac.ir/browse.php?a_code=A-10-33-2&slc_lang=en&sid=1 Asra Margdari اسرا مرگدری 10031947532846001293 10031947532846001293 No Soheila Ebrahimi سهیلا ابراهیمی 10031947532846001294 10031947532846001294 No Hamid Sepehri حمید سپهری 10031947532846001295 10031947532846001295 Yes