en Biochemistry پژوهشي Research <p>&nbsp;</p> <div style="text-align: justify;"><span style="font-size:12px;"><span style="font-family:Times New Roman;"><b>Background:</b> This study investigated the role of PPARG genetic variants in type 2 diabetes mellitus complications among individuals in Ekiti State, Nigeria. The focus was on understanding how these genetic variants may influence biochemical markers and, consequently, the risk of complications.<br> <b>Methods:</b> We recruited 74 diabetic patients and 20 controls from a university teaching hospital. Ten milliliters of whole blood samples were collected by venipuncture and divided into two 5-milliliter aliquots. One aliquot was placed in an EDTA bottle, and the other in a fluoride oxalate bottle, before centrifugation to obtain plasma. PPARG genotyping and biochemical marker analyses, including Cystatin C, ALT, CK-MB, and IL-10, were performed.<br> <b>Results:</b> Significant differences in PPARG genotype distribution were observed, with the GG genotype being more common in diabetic individuals. Diabetic subjects showed elevated Cystatin C, ALT, and CK-MB levels, along with reduced IL-10, particularly among females. PPARG genotypes were associated with several biochemical markers, notably Cystatin C (p = 0.002), ALT (p = 0.030), and FBS (p = 0.017).<br> <b>Conclusion</b>: These findings highlight a complex relationship between PPARG genotypes and the pathophysiology of diabetes in the Nigerian population, emphasizing the potential for personalized medicine approaches in type 2 diabetes mellitus management.</span></span></div> PPARG Protein, Diabetes Mellitus, Type 2, Pharmacogenomic Variants, Biomarkers, Nigeria 1 4 http://jcbr.goums.ac.ir/browse.php?a_code=A-10-520-2&slc_lang=en&sid=1 David Olufemi Adebo daveadebo@gmail.com 10031947532846005854 0009-0004-5129-4982 No Medical Laboratory Science Department, Edo State University, Uzairue, Edo State, Nigeria ; Chemical Pathology Department, Ekiti State University Teaching Hospital, Ado-Ekiti, Ekiti State, Nigeria Mathew Folaranmi Olaniyan olaniyanmat@yahoo.com 10031947532846005855 10031947532846005855 No Medical Laboratory Science Department, Edo State University, Uzairue, Edo State, Nigeria Gabriel Olufemi Daramola gabrielodaramola@yahoo.com 10031947532846005856 10031947532846005856 No Medical Microbiology and Parasitology Department, Ekiti State University Teaching Hospital, Ado-Ekiti, Ekiti State, Nigeria ; Medical Laboratory Science Department, College of Medicine, Ekiti State University, Ado-Ekiti, Ekiti State, Nigeria Christian Onosetale Ugege chrisugege86@gmail.com 10031947532846005857 0009-0001-6294-6112 No Medical Laboratory Science Department, Edo State University, Uzairue, Edo State, Nigeria Odekunle Bola Odegbemi odegbemi21.odekunle@edouniversity.edu.ng 10031947532846005858 10031947532846005858 Yes Medical Laboratory Science Department, Edo State University, Uzairue, Edo State, Nigeria;Medical Laboratory Science Department, Nigerian Navy Hospital, Warri, Delta State, Nigeria